抗炎新分子的研究

The 2nd International Electronic Conference on Biomedicines Pub Date : 2023-03-01 DOI:10.3390/ecb2023-14095

Abel Vale, M. Lucas, D. Ribeiro, E. Fernandes

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引用次数: 0

摘要

目前可用的环氧化酶-2 (COX-2)抑制剂增加了心血管事件的风险，这证明了寻找新的替代抗炎分子的合理性。本工作旨在评价查尔酮(多羟基化芳香化合物):2 (cid:48)，3,4,4 (cid:48)，6 (cid:48) -五羟基查尔酮(5OH)， 2 (cid:48)，3,4,4 (cid:48)，6 (cid:48) -五甲基查尔酮(5OMe)和2 (cid:48)，3,4,4 (cid:48) -四羟基查尔酮(丁蛋白)在实验人体全血模型中的抗炎活性。结果表明，所研究的查尔酮对人体血细胞没有细胞毒性。在所测试的查尔酮中，丁蛋白是唯一一种在人血液中通过COX-2抑制前列腺素e2产生的浓度依赖性物质(40±8%，50µM)。

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Research into New Molecules with Anti-Inflammatory Activity

: The drugs currently available as cyclooxygenase-2 (COX-2) inhibitors increase the risk of cardiovascular events, which justiﬁes the search for new alternative anti-inﬂammatory molecules. This work aimed to evaluate the anti-inﬂammatory activity of the chalcones (polyhydroxylated aromatic compounds): 2 (cid:48) ,3,4,4 (cid:48) ,6 (cid:48) -pentahydroxychalcone (5OH), 2 (cid:48) ,3,4,4 (cid:48) ,6 (cid:48) -pentamethoxychalcone (5OMe), and 2 (cid:48) ,3,4,4 (cid:48) -tetrahydroxychalcone (butein), at non-cytotoxic concentrations, in an experimental human whole blood model. The results obtained showed that none of the chalcones under study was cytotoxic to human blood cells. From the tested chalcones, butein was the only one showing a concentration-dependent inhibitory production of prostaglandin E 2 , via COX-2, in human blood (40 ± 8%, at 50 µ M).

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The 2nd International Electronic Conference on Biomedicines

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