A. Kogure, N. Saito, Koichi Soyama, Makio Kobayashi, S. Kameoka
{"title":"血清整合素β1水平作为转移性结直肠癌的预后指标","authors":"A. Kogure, N. Saito, Koichi Soyama, Makio Kobayashi, S. Kameoka","doi":"10.4030/JJCS.36.594","DOIUrl":null,"url":null,"abstract":"Received: January 7, 2011/Accepted: April 27, 2011 Correspondence to: Akiko Kogure Department of Surgery II, Tokyo Women’s Medical University School of Medicine, 8-1Kawada-cho, Shinjuku-ku, Tokyo 162-8666 , Japan Abstract Aims : In this study, we examined whether the integrin β1 subunit, thought to play an important role in colorectal cancer invasion and metastasis, can be used as a prognostic marker for colorectal cancer. Patients and Methods : The subjects of this study were 86 patients who underwent surgery for colorectal cancer at this department. We measured preoperative serum integrin β1 levels and conducted a 5 year retrospective postoperative study, examining the relationship between integrin β1 levels and survival curves. Results: For patients with postoperative recurrence or metastasis, outcomes were significantly better in those with a preoperative serum integrin β1 level 600 ng/mL than those with <600 ng/mL (p=0.0062). Conclusions: Even in patients with metastases identified preoperatively, outcomes were favourable if preoperative serum integrin β1 levels were high. These results indicate that integrin β1 shows promise as a prognostic marker in metastatic colorectal cancer.","PeriodicalId":286696,"journal":{"name":"Nihon Gekakei Rengo Gakkaishi (journal of Japanese College of Surgeons)","volume":"17 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2011-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Serum Integrin β1 Levels as a Prognostic Marker in Metastatic Colorectal Cancer\",\"authors\":\"A. Kogure, N. Saito, Koichi Soyama, Makio Kobayashi, S. Kameoka\",\"doi\":\"10.4030/JJCS.36.594\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Received: January 7, 2011/Accepted: April 27, 2011 Correspondence to: Akiko Kogure Department of Surgery II, Tokyo Women’s Medical University School of Medicine, 8-1Kawada-cho, Shinjuku-ku, Tokyo 162-8666 , Japan Abstract Aims : In this study, we examined whether the integrin β1 subunit, thought to play an important role in colorectal cancer invasion and metastasis, can be used as a prognostic marker for colorectal cancer. Patients and Methods : The subjects of this study were 86 patients who underwent surgery for colorectal cancer at this department. We measured preoperative serum integrin β1 levels and conducted a 5 year retrospective postoperative study, examining the relationship between integrin β1 levels and survival curves. Results: For patients with postoperative recurrence or metastasis, outcomes were significantly better in those with a preoperative serum integrin β1 level 600 ng/mL than those with <600 ng/mL (p=0.0062). Conclusions: Even in patients with metastases identified preoperatively, outcomes were favourable if preoperative serum integrin β1 levels were high. These results indicate that integrin β1 shows promise as a prognostic marker in metastatic colorectal cancer.\",\"PeriodicalId\":286696,\"journal\":{\"name\":\"Nihon Gekakei Rengo Gakkaishi (journal of Japanese College of Surgeons)\",\"volume\":\"17 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2011-08-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nihon Gekakei Rengo Gakkaishi (journal of Japanese College of Surgeons)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4030/JJCS.36.594\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nihon Gekakei Rengo Gakkaishi (journal of Japanese College of Surgeons)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4030/JJCS.36.594","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Serum Integrin β1 Levels as a Prognostic Marker in Metastatic Colorectal Cancer
Received: January 7, 2011/Accepted: April 27, 2011 Correspondence to: Akiko Kogure Department of Surgery II, Tokyo Women’s Medical University School of Medicine, 8-1Kawada-cho, Shinjuku-ku, Tokyo 162-8666 , Japan Abstract Aims : In this study, we examined whether the integrin β1 subunit, thought to play an important role in colorectal cancer invasion and metastasis, can be used as a prognostic marker for colorectal cancer. Patients and Methods : The subjects of this study were 86 patients who underwent surgery for colorectal cancer at this department. We measured preoperative serum integrin β1 levels and conducted a 5 year retrospective postoperative study, examining the relationship between integrin β1 levels and survival curves. Results: For patients with postoperative recurrence or metastasis, outcomes were significantly better in those with a preoperative serum integrin β1 level 600 ng/mL than those with <600 ng/mL (p=0.0062). Conclusions: Even in patients with metastases identified preoperatively, outcomes were favourable if preoperative serum integrin β1 levels were high. These results indicate that integrin β1 shows promise as a prognostic marker in metastatic colorectal cancer.