Neuromyelitis Optica Spectrum Disorder: A Rare Case Report

Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease that causes demyelination, especially in the optic nerve and spinal cord with typical manifestations of acute optic neuritis and transverse myelitis. 30-year-old male presented with complaints of breathlessness, sudden loss of vision and weakness of all four limbs since 2 days. On neurological examination found weakness in all four limbs with exaggerated deep tendon reflex. Blood tests were within normal limits. He was treated with pulse steroid therapy that is 1gm of methylprednisolone IV for 5 days but no improvement was noted. This is a case of neuromyelitis optica spectrum disorder which shown no improvement with pulse steroid therapy. Keywords: Neuromyleitis optica, Antibody, Aquaporin-4