SAGE提取物对腹泻患者和一种癌症细胞分离的细菌生长的潜在作用

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On the other hand, cytotoxic effects of the ethanol extract\nof Salvia showed antitumor activity on MCF-7 cells in a dose-dependent manner\nas the cell viability against MCF-7 cells was decreased with an IC50 of μg/ml.\nThe experimental study of the antibacterial influence of extracted sage plants\nfrom ethanol on the evolution of multi-drug resistant bacteria was fulfilled with\ngood diffusion at different concentrations: 50, 150, 200 mg/mL, and microdilution methods. Disclose the impact of the sage methanol extract on MCF-7 cell viability.\nIn our study, Ethanol extracts of sage in the good diffusion method displayed obvious notable inhibitory against bacterial growth. These results refer to the inhibitory impacts of ethanol extract of sage with MIC (Minimum Inhibitory Concentration)=8 mg/mL owing to S.aureus, MIC=5 mg/mL for E. coli, MIC=4.4\nmg/mL owing to P. aeruginous, MIC=4.2 mg/mL owing to Burkholderia,\nMIC=5.7 mg/mL owing to Klebsiella pneumonia. 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引用次数: 0

摘要

现在,在药物和药用药物的开发中开始使用某些类型的草药,包括鼠尾草,而不是合成药物,因为它们具有抗菌作用,被认为是防止食物变质的防腐剂。鼠尾草也是一种用作食品调味品的芳香材料。本研究考察了鼠尾草提取物对四种病原菌和耐药菌的体外抑菌作用,如金黄色葡萄球菌、大肠杆菌、绿脓杆菌,以及肺炎克雷伯菌、普罗维登斯菌和伯克霍尔德菌。另一方面,丹参乙醇提取物对MCF-7细胞的细胞毒作用呈剂量依赖性,抑制MCF-7细胞的活性,IC50为μg/ml。采用不同浓度(50、150、200 mg/mL)和微量稀释法对鼠尾草乙醇提取物对多重耐药菌进化的抑菌作用进行了实验研究。揭示鼠尾草甲醇提取物对MCF-7细胞活力的影响。在我们的研究中,鼠尾草乙醇提取物在良好扩散法下对细菌的生长有明显的抑制作用。这些结果是指鼠尾草乙醇提取物对金黄色葡萄球菌的最低抑制浓度MIC= 8 mg/mL,对大肠杆菌的最低抑制浓度MIC=5 mg/mL,对铜绿假单胞菌的最低抑制浓度MIC=4.4mg/mL,对伯克氏菌的最低抑制浓度MIC=4.2 mg/mL,对肺炎克雷伯菌的最低抑制浓度MIC=5.7 mg/mL。与普罗维登西亚发现的影响。结果表明,在250µg mLG1时,生长抑制率为63.18%,呈剂量依赖性。关于鼠尾草乙醇提取物对多药不透菌的抗菌作用,建议在药理学研究后使用草药替代抗生素进行治疗。鼠尾草甲醇提取物对MCF-7细胞具有较强的细胞毒活性。关键词:鼠尾草,鼠尾草,抗菌活性,细胞毒性,MCF-7细胞系
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Potential action of SAGE extracts to prevent the growth of bacteria isolated from patients suffering from diarrhea and one type of cancer cell
Now, the trend has begun to use some types of herbs, including salvia sage, in the development of medicines and medicinal drugs instead of synthetic drugs because they are antimicrobial and are considered preservatives against food spoilage. Sage is also an aromatic material used as a food flavoring. This work represented examining the antibacterial impact of the sage extract on four types of pathogenic and drug-resistant bacteria in vitro, like Staphylococcus aureus, Escherichia coli, Pseudomonas eruginosa, besides Klebsiella pneumonia, Providencia, and Burkholderia. On the other hand, cytotoxic effects of the ethanol extract of Salvia showed antitumor activity on MCF-7 cells in a dose-dependent manner as the cell viability against MCF-7 cells was decreased with an IC50 of μg/ml. The experimental study of the antibacterial influence of extracted sage plants from ethanol on the evolution of multi-drug resistant bacteria was fulfilled with good diffusion at different concentrations: 50, 150, 200 mg/mL, and microdilution methods. Disclose the impact of the sage methanol extract on MCF-7 cell viability. In our study, Ethanol extracts of sage in the good diffusion method displayed obvious notable inhibitory against bacterial growth. These results refer to the inhibitory impacts of ethanol extract of sage with MIC (Minimum Inhibitory Concentration)=8 mg/mL owing to S.aureus, MIC=5 mg/mL for E. coli, MIC=4.4 mg/mL owing to P. aeruginous, MIC=4.2 mg/mL owing to Burkholderia, MIC=5.7 mg/mL owing to Klebsiella pneumonia. The impact found with Providencia. Results indicated a dose-dependently growth inhibition (63.18% at 250 µg mLG1 ). Concerning the antibacterial impact of ethanol extracts of Sage on the multi-drug impervious to bacteria, the use of herbs as a replacement to antibiotics after pharmacological studies for treatment is recommended. Methanol extract of sage exhibited profound cytotoxicity activity against the MCF-7 cell line. Keywords: Salvia sclarea, sage, Antibacterial activity, cytotoxicity, MCF-7 cell line.
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