Gülşah Alyar, Nuri Öztürk, Özgü Yörük, Özge Nur Türkeri̇, Nuri Bakan
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摘要

目的:本研究旨在评估梗阻性腺扁桃体肥大患儿的术前和术后氧化应激水平,并与健康儿童进行比较。材料与方法:本前瞻性研究于2015年3月至9月进行,纳入25例患者和25例健康对照。在研究样本中,诊断为慢性扁桃体炎、打鼾和口呼吸导致的腺扁桃体肥大并计划行腺扁桃体切除术的儿童被纳入患者组。对照组包括25名具有相同人口统计学特征的健康志愿者。患者组术前、术后各采集两次血清和尿液样本,对照组各采集一次。采用EIA法测定8-羟基-2-脱氧鸟苷水平,ELISA法测定蛋白质羰基水平,手工分光光度法测定丙二醛水平。结果:本研究发现腺扁桃体肥大患儿血清丙二醛水平显著高于对照组(p=0.003),其他参数差异无统计学意义(p>0.05)。术后3项指标均较术前显著降低(p<0.05)。确定术前丙二醛与8-羟基-2-脱氧鸟苷值有统计学意义,相关性较弱(p=0.003, r=0.566)。结论:增生性腺扁桃体常见于儿科人群,可引起多种临床症状,影响儿童健康和生活质量。根据我们的研究结果,我们可以说,血清和尿液mdal水平以及组织PCO水平是评估梗阻性ATH患儿氧化损伤的有用指标,可能有助于阐明该疾病的发病机制。考虑到ATH对健康的影响,建议将其视为一个重要的健康问题,并在更大的样本组中检查该疾病的临床、生化和组织病理学研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Çocuklarda Oksidatif Stres ile Adenotonsiller Hipertrofi Arasındaki İlişki
Objective: In this study, it was aimed to evaluate the preoperative and postoperative oxidative stress levels of children with obstructive adenotonsillar hypertrophy and to compare the obtained data with healthy children. Material and Methods: 25 patients and 25 healthy controls were included in the prospective study conducted between March and September 2015. In the study sample, children who were diagnosed with adenotonsillar hypertrophy due to chronic tonsillitis, snoring and mouth breathing and who were planned for adenotonsillectomy were included in the patient group. Control group included 25 healthy volunteers with the same demographic characteristics. Serum and urine samples were collected from the patient group twice, before and after surgery, and once from the control group. 8-hydroxy-2-deoxyguanosine levels of all samples were determined by EIA method, protein carbonyl levels were determined by ELISA method and malondialdehyde levels were determined by manual spectrophotometric method. Results: In the study, it was found that the serum malondialdehyde levels of children with adenotonsillar hypertrophy were significantly higher than the control group (p=0.003) and that there was no difference in terms of other parameters (p>0.05). After the operation, it was determined that the levels of all three parameters evaluated significantly decreased compared to before (p<0.05). It was determined that there was a statistically significant and weak correlation between malondialdehyde and 8-hydroxy-2-deoxyguanosine values before the operation (p=0.003, r=0.566). Conclusion: Hypertrophic adenotonsillar, which is common in the pediatric population, causes many clinical conditions and adversely affects the health and quality of life of children. In line with our findings, we can say that serum and urine MDA levels and tissue PCO levels are useful markers in the evaluation of oxidative damage in children with obstructive ATH and may help to elucidate the etiopathogenesis of the disease. Considering the effects of ATH on health, it is recommended to be considered as an important health problem and to examine the clinical, biochemical and histopathological studies of the disease in a larger sample group.
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