Ophiopogon Japonicus Polysaccharide Plays an Anti-esophageal Cancer Role Through Antioxidant Activity

As a natural product with a variety of biological activities, plant polysaccharide has become a research highlight in the field of antioxidant activity and anti-tumor due to its high efficiency and low toxicity. In this study, the antioxidant and anti-tumor activities of Ophiopogon japonicus polysaccharides (OJP) in vitro and in vivo were investigated. The results showed that OJP had obvious scavenging ability on hydroxyl radical and superoxide radical in a dose-dependent manner. Moreover, the reducing power of OJP also increased and appeared to be dose-dependent. In vivo, it reduced the accumulation of lipofuscin and induced cell apoptosis of Caenorhabditis elegans. In addition, it significantly inhibits the viability of esophageal cancer cell lines Eca109 and TE-1 in vitro and promoted their apoptosis. In conclusion, OJP avoids oxidative damage of organisms and plays an anti-tumor role via its antioxidation. This study aims to promote the in-depth study of plant polysaccharides and provide theoretical reference for the development of antioxidant foods and anti-tumor drugs.