体育锻炼计划是预防早期乳腺癌心脏毒性的一种策略:文献综述

Quentin Jacquinot, N. Méneveau, B. Degano, F. Mougin
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引用次数: 2

摘要

乳腺癌在女性中最常见,是一种预后良好的癌症。在过去十年中,癌症筛查和治疗的改进显著提高了无病生存率和总生存率。然而,化疗,尤其是基于蒽环类药物的化疗,以及曲妥珠单抗等靶向治疗对心血管系统有毒性。如果体育锻炼被认为有利于三级预防,特别是通过减少疲劳,提高运动的生理能力,肌肉力量和最终的生活质量,相反,很少有数据表明运动对治疗性心脏毒性的影响。本综述基于PubMed数据库,介绍了临床前和临床研究结果,表明体育锻炼通过其心脏保护作用,增加抗氧化能力,减少氧化应激,使左心室射血分数保持在正常值,并在治疗期间和治疗后改善舒张功能。定期的体育锻炼应该是肿瘤学支持治疗的一个组成部分,但在未来的研究中,确定其模式以更好地预防治疗的心脏毒性是必要的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Physical exercise program, a strategy to prevent cardiotoxicity in early breast cancer: A literature review
Breast cancer, the most common in women, is a cancer of good prognosis. During this last decade, the improvement of cancer screening and treatment has significantly increased disease-free and overall survival. However, the chemotherapy, especially based on anthracyclines, and targeted therapies like trastuzumab have a toxicity to the cardiovascular system. If physical exercise is recognized as beneficial in tertiary prevention, especially by reducing fatigue, improving the physiological capacities of exercise, muscle strength and ultimately quality of life, conversely, few data are available on the effects of exercise on treatment-induced cardiotoxicity. This review, based on the PubMed database, presents the results of preclinical and clinical studies showing that physical exercise, by its cardioprotective role, increases the antioxidant capacity, reduces oxidative stress, maintains the left ventricular ejection fraction at a normal value and improves diastolic functions during and after treatment. Regular physical exercise should be an integral part of supportive care in oncology but it is necessary, in future studies, to determine its modalities for a better prevention of the cardiotoxicity of the treatments.
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