Features of violations of menstrual and genesial function at combined pathology of uterus

The objective: study of nosotropic aspects of violations of menstrual and genesial function at combined pathology of uterus. Materials and methods. For the decision of the put purpose we conducted a complex clinical and laboratory, functional and immunohistochemical inspection 109 women with combined pathology of uterus and violation of genesial function. 1 (n=69) and 2 (n=19) groups were formed from patients with chronic endometritis and concomitant genital pathology. In 3 (n=21) groups there were the included women after different endometrial manipulations. For the study of new aspects of pathogeny of violation of genesial function for women with combined pathology of uterus immunohistochemical researches of endometrium conducted the method of double antibodies with immunoperoxidase (streptovidin-biotinic) by a mark, used serial paraffin cuts. Results. The retrospective study of the given medicare rotined that a desire to have children had served by reason of active treatment at the most inspected women. Anti-inflammatory (including antibacterial) therapy is before conducted at 93,3% patients, thus in the half of cases – repeatedly. Hormonal preparations were before appointed 66,2% to the patients. Endoscopic surgical interferences on the organs of the genesial system are executed for 46,7% patients. Used the more than half of women programs of auxiliary reproductive technologies which did not bring the desired effect. The results of laboratory-instrumental inspection confirmed a presence different structurally functional changes of endometrium, which could be an independent factor, impedimental to implantation and successful development of pregnancy. The increase of proangiogenic potential plays a considerable role in pathogeny of combined pathology of uterus and violations of genesial function. Conclusions. Combined pathology of uterus is reason of violations of genesial function of women. The set nosotropic features testify to the necessity of more deep study of this problem for development of effective algorithm of diagnostic and лечебно-профилактических measures.