不同时间脉冲电场对细胞色素c释放的影响

The 2012 International Workshop on Microwave and Millimeter Wave Circuits and System Technology Pub Date : 2012-04-19 DOI:10.1109/MMWCST.2012.6238126

Hao-tse Wu, M. Wu, Heng Zou

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引用次数: 0

摘要

采用多层介电球模型(MDSM)分析细胞对脉冲电场(pef)的响应，当考虑线粒体亚结构时，细胞色素c释放是脉冲电场的显著影响。MDSM模型的数值结果解释并验证了细胞内电操作(IEM)的实验结果。提出细胞色素c的释放可通过生物电脉冲作用于线粒体实现两步过程。

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Cytochrome c release caused by Pulsed Electric Fields (PEFs) with different time durations

Multilayer Dielectric Sphere Model (MDSM) is used for analyzing responses of cells to Pulsed Electric Fields (PEFs), and cytochrome c release is significant effect of PEFs when mitochondrial substructures are taken into account. Numerical results of MDSM model explain and verify the reported experimental results on Intracellular Electro-manipulation (IEM). It is proposed that two-step process of cytochrome c release can be implemented by bioelectric impulse effect on mitochondria.

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The 2012 International Workshop on Microwave and Millimeter Wave Circuits and System Technology

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