超短脉冲电穿孔:应用高脉冲电场诱导人淋巴细胞半胱天冬酶活化

Conference Record of the Twenty-Fifth International Power Modulator Symposium, 2002 and 2002 High-Voltage Workshop. Pub Date : 2002-06-30 DOI:10.1109/MODSYM.2002.1189565

M. Gundersen, P. Vernier, L. Marcu, Aimin Li, X. Zhu, A.Z. Gallam, T. Katsouleas, C. Young, M. Behrend, C. Craft

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引用次数: 23

摘要

提供了短时间强电场(10秒)诱导的细胞凋亡或程序性细胞死亡和一组重要基因上调的证据。观察到电场干扰线粒体膜和Jurkat T淋巴细胞的区隔细胞内环境，并在数小时内发生caspase激活。强但低能量的电场可以穿透生物细胞并触发与细胞凋亡相关的机制。

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Ultrashort pulse electroporation: applications of high pulsed electric fields to induced caspase activation of human lymphocytes

Presents evidence for apoptosis, or programmed cell death, and up-regulation of a subset of important genes induced by intense electric fields of short duration (10's nsec). The fields are observed to perturb mitochondrial membranes and the compartmentalized intracellular environment of Jurkat T lymphocytes, and within hours caspase activation occurs. Intense, but low energy, fields can penetrate a biological cell and invoke mechanisms associated with apoptosis.

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Conference Record of the Twenty-Fifth International Power Modulator Symposium, 2002 and 2002 High-Voltage Workshop.

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