IL-9在过敏性和自身免疫性疾病中的治疗潜力

Ahmed Ummey Khalecha Bintha, Amani Souwelimatou Amadou, Mursalin Md Huzzatul, Muhammad Fauziyya
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引用次数: 0

摘要

白细胞介素-9 (IL-9)是一种由多种免疫细胞和上皮细胞产生的多效细胞因子。近年来,许多研究都回避了IL-9及其谱系特异性辅助性T细胞亚群(Th9)的生理和病理作用。在本章中,我们将重点讨论白细胞介素9 (IL-9)在过敏和自身免疫中的免疫学作用。我们将介绍IL-9的基础知识,并描述参与IL-9分泌、信号传导和调节的细胞。在建立背景之后,我们将讨论IL-9在过敏性和自身免疫性疾病中的发病机制和调控。我们将通过提供针对IL-9的最新治疗方法及其在自身免疫性和过敏性疾病中的潜在应用来结束本章。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Therapeutic Potential of IL-9 in Allergic and Autoimmune Diseases
Interleukin-9 (IL-9) is a pleiotropic cytokine produced by several immune and epithelial cells. Recently, many studies have eluded the physiological and pathological roles of IL-9 and its lineage-specific helper T cell subset (Th9). In this chapter, we will focus on the immunological role of Interleukin 9 (IL-9) in allergy and autoimmunity. We will introduce the basics of IL-9 and describe the cells involved in the secretion, signaling, and regulation of IL-9. After establishing the background, we will discuss the pathogenesis and regulation of IL-9 in allergic and autoimmune diseases. We will conclude the chapter by providing an updated therapeutics that target IL-9 and their potential uses in autoimmune and allergic diseases.
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