散发性肾癌的分子遗传学和细胞遗传学特征:文献综述

Cancer Urology Pub Date : 2022-12-10 DOI:10.17650/1726-9776-2022-18-3-107-115

S. Popov, R. Guseynov, O. Skryabin, V. V. Perepelitsa, A. V. Davydov, R. S. Barkhitdinov, A. Katunin, M. M. Mirzabekov

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引用次数: 0

摘要

为了编写这篇文献综述，我们研究了至少100篇关于透明细胞癌、乳头状癌和疏色性散发性肾癌发病机制的遗传基础的出版物。他们都考虑了体细胞基因和染色体突变在散发性肾细胞癌的发生、促进和肿瘤进展中的作用，强调了确定肾细胞癌的致突变谱对患者未来命运的重要性。

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Molecular-genetic and cytogenetic characteristics of sporadic kidney cancer: literature review

To compile this literature review, we studied at least 100 publications devoted to the genetic basis of clear cell, papillary, and chromophobic sporadic kidney cancer pathogenesis. Each of them considered the role of somatic gene and chromosomal mutations in the initiation, promotion, and tumor progression of sporadic renal cell carcinoma, emphasized the importance of determining the mutagenic profile of renal cell carcinoma for the future fate of patients.

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Cancer Urology

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