马来西亚巴生谷孕妇血铅浓度与神经心理学评分

Shamsul Bahari Shamsudin, J. Hashim, N. Ismail, M. P. Koentjoro
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摘要

高血铅孕妇对胎儿有很高的风险,因为胎盘移植可能发生在胎儿身上。本研究的目的是确定在妊娠晚期的妇女血铅和神经心理评分之间的关系。这些答复者正在巴生谷地区的一家教学医院接受例行产前检查。采用石墨炉原子吸收分光光度计(AAS)测定血铅浓度。神经心理学评分采用WHO神经行为核心测试(NCTB)。测试包括数字符号测试、轨迹测试、数字广度测试、本顿视觉保持测试、追踪瞄准测试、圣安娜手敏捷测试、反应时间测试和运动时间测试等7个项目。平均血铅为7.78±4.77µg/dL。NCTB总测试平均得分为50.00±5.24。血铅浓度与NCTB总分呈负相关(r= -0.462, p≤0.01)。相关性约为21.3%。一般线性模型(GLM)显示,年龄(β= -0.15, p=0.017)、体重(β=2.67, p=0.05)和身高(β= -1.97, p=0.05)也影响神经心理总分。总之,血铅降低了神经心理学总分。除Trail Making和Santa Ana Manual Dexterity测试外,7个项目的得分均与血铅浓度呈显著负相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
BLOOD LEAD CONCENTRATIONS AND THE NEUROPSYCHOLOGY SCORES OF PREGNANT WOMEN IN KLANG VALLEY, MALAYSIA
Pregnant women with high blood lead posed high risk to their fetus as placental transfer can occurs to the fetus. The objective of this study was to identify the relationship between blood lead and the neuropsychological score of women who were in their 3rd trimester of pregnancy. These respondents were undergoing a routine antenatal checkup at a teaching hospital located in Klang Valley areas.  Blood lead concentrations were analyzed using graphite furnace Atomic Absorption Spectrophotometer (AAS). The neuropsychological scores were measured with WHO Neurobehavioral Core Test battery (NCTB). The test consists of 7 items, which made up of the Digit Symbol, Trail Making, Digit Span, Benton Visual Retention Test, Pursuit Aiming, Santa Ana Manual Dexterity, Reaction Time and Movement Time tests. The mean blood lead was 7.78±4.77 µg/dL. The mean score for the total NCTB test was 50.00±5.24. Statistical analysis showed blood lead concentrations were inversely correlated with the total NCTB score (r= –0.462, p≤0.01). The correlation was about 21.3%. The General Linear Model (GLM) showed that age (β= –0.15, p=0.017), weight (β=2.67, p=0.05) and height (β=–1.97, p=0.05) also influence the total neuropsychological scores. In conclusion, blood lead reduces the total neuropsychological scores. The scores for each of the 7 items were inversely and significantly correlated with blood lead concentrations except for the Trail Making and Santa Ana Manual Dexterity tests.
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