H R Brunner, H Gavras, G A Turini, B Waeber, P Cappuis, D N McKinstry
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Long-term treatment of hypertension in man by an orally active angiotensin-converting enzyme inhibitor.
1. Captopril or SQ 14 225, administered orally twice a day, reduced the blood pressure of hypertensive patients whatever their clinical diagnosis and even when their plasma renin activity was 'normal' or low. 2. Long-term administration of captopril, either alone or together with diuretics, provides a powerful new tool with which to treat ambulatory hypertensive patients. 3. The renin system may play an important role in maintaining blood pressure in a majority of hypertensive patients.
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