A review on monkey pox

Monkey pox a vesiculo pustular rash illness was initially discover to cause human infection in 1970 through the world health organization (WHO) -sponsered efforts of the commission to certify small pox eradication In western Africa and the congo basin . the virus has been discovered to cause a non human primate rash illness in 1958 and was thus named monkey pox the causative agents of small pox and monkey pox disease both are species of orthopox virus,monkey pox when it effects human as an epizootic produces a similar clinical picture to that of ordinary human smallpox since 1970 extensive epidemiology, virology,ecology, and public health research has enable better characterization of monkey pox virus and the associated human disease .we conducted a sysmatic review of peer-reviewed and grey literacture on how monkey pox epidimology has evolved, with particular  emphasis on the number of confirmed, probable ,  and possible cases,age at presentation and geographical spread. The number of human monkey pox cases has been on the rise since the 1970s ,with the most dramatic increases occurring in the DRC . The median age at presentation has increased from 4 1970s) to 21 years ( 2010-2019).There was an overall case fatality rate of 8.7% with a significant difference between clades -central African  10.6% ( 95% CI: 8.4%-13.3% ) VS WestAfrican 3.6% ( 95% CI:1.7%-6.8% ) .your review shows an escalation of monkey pox cases, especially in the highly endemic DRC , a spread to other  countries, and  a growing median age from young children to young adults . These findings may be related to the cessation of small pox vaccination , which  provided some cross -protection against monkeypox , leading to increased human -to -human transmission. increased  surveillance and detection of monkeypox cases are essential tools for understanding the continousily changing  epidemiology of this resurging disease.