体内防御屏障:多药耐药相关蛋白的作用

C. Dietrich, A. Geier, R. P. Elferink, S. Matern
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引用次数: 0

摘要

多药耐药相关蛋白2 (MRP2,基因命名为ABCC2)是atp结合盒(ABC-)转运蛋白家族的一员,存在于肝细胞的管状膜、肠细胞和肾小管上皮细胞的顶膜中。在所有这些屏障中,MRP2有助于减少潜在有毒的异种抗生素和内源性废物的身体负荷。MRP2的这一重要的“看门人”功能最近得到了认识,这里回顾了有关该功能的数据。在这些屏障的功能中,MRP2是一个复杂的解毒途径的一部分,该途径由核受体作为常见的激活剂调节。然而,MRP2也可以通过在胆管中集中有毒物质和降低保护性化合物的生物利用度来介导毒性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Defense Barriers in the Body:Contribution of Multidrug Resistance-Associated Protein 2
Multidrug resistance-associated protein 2 (MRP2, gene nomenclature ABCC2), a member of the family of ATP-binding cassette (ABC-) transporters, is present in the canalicular membrane of hepatocytes and in the apical membrane of enterocytes and renal tubule epithelial cells. At all of these barriers, MRP2 contributes to reduction of the body load of potentially toxic xenobiotics and endogenous waste products. This important “gatekeeper” function of MRP2 has been recognized recently, and data regarding this function are reviewed here. In its function at these barriers, MRP2 is part of a complex detoxification pathway that is regulated by nuclear receptors as common activators. However, MRP2 also can mediate toxicity by concentrating toxicants in the biliary duct and reducing the bioavailability of protective compounds.
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