猴痘流行的全球和地方高潮:当前趋势、挑战和未来前景

Enitan Ss
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摘要

在全球放松对2019冠状病毒病(COVID-19)的干预措施,庆祝在抗击大流行中取得的前所未有的胜利之际,猴痘病毒(MPXV)在许多国家出现并重新出现,占据了全球各大媒体的头条。自2022年1月1日至6月22日,世卫组织五个区域(非洲、美洲、东地中海、欧洲和西太平洋)的50个国家和领土报告了3413例实验室确诊病例;还有一人死亡。 尼日利亚疾病控制中心(NCDC)于2017年9月22日收到巴耶尔萨州可能发生猴痘疫情的通知。此后,从巴耶尔萨到里弗斯、埃基蒂、阿夸伊博姆、拉各斯、奥贡和克罗斯河,猴痘祸害在尼日利亚首次报告该疾病五(5)年后继续升级。2017年9月至2022年6月26日,全国25个州共记录了716例疑似病例。在716例疑似病例中,25个州确诊288例(40.2%)。到目前为止,在2017年9月至2022年6月期间,6个州共报告了9例死亡(病死率=3.1%)。目前,以下挑战正在阻碍该国有效遏制该病毒:1)由于污名、成本和低死亡率,患者对卫生保健设施的使用率较低;2)由于无法充分利用保健设施而漏报病例;3)报告州样本采集率低;4)偏远地区传染病实验室支持不足;5)本届政府腐败,缺乏抗击病毒的政治意愿;6)猴痘监测薄弱,可能与卫生人力有限和COVID - 19大流行应对有关;7)在追求建立全球卫生公平方面缺乏国际合作、团结和协调;8)除其他外,无法获得授权和安全的治疗和疫苗。尽管面临这些挑战,一个无猴痘的尼日利亚是可能的。为此目的,对公众进行安全有效的免疫接种,如对天花、脊髓灰质炎和黄热病进行免疫接种,是未来的关键。在安全有效的疫苗唾手可得之前,控制和预防主要依靠非药物干预措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Global and Local Upsurge in Monkey pox Epidemic: Current Trends, Challenges and Future Prospects
Amidst global relaxation of the Coronavirus Disease 2019 (COVID-19) intervention measures and celebration of the unprecedented grounds conquered in the fight against the pandemic, the monkeypox virus (MPXV) has emerged and remerged in many countries taking over major headlines around the globe at the present. Since 1 January and as of 22 June 2022, 50 nations and territories in five WHO Regions (Africa, America, Eastern Mediterranean, Europe, and Western Pacific) have reported 3413 laboratory-confirmed cases; along with one fatality. The Nigeria Centre for Disease Control (NCDC) received notice of a possible monkeypox epidemic in Bayelsa State on September 22, 2017. Thereafter, from Bayelsa to Rivers, Ekiti, Akwa Ibom, Lagos, Ogun and Cross River, the scourge of Monkeypox has continue to escalate five (5) years after the disease was first reported in Nigeria. An aggregate of 716 suspected cases have been recorded from 25 states nationwide between September 2017 and June 26, 2022. There have been 288 (40.2 percent) confirmed cases from 25 states out of the 716 suspected cases. So far, nine (9) deaths in total (CFR=3.1%) have been reported in 6 states between September 2017 and June 2022. At the moment, the following challenges are preventing the country from containing the virus effectively: 1) Low patient use of healthcare facilities because of stigma, cost, and low fatality rate; 2) Underreporting of cases due to inadequate access to healthcare facilities; 3) Low sample collection rate in reporting states; 4) Poor infectious disease laboratories support in remote areas; 5) Corruption and lack of political will by current administration to fight the virus; 6) Weak monkeypox monitoring, possibly related to a limited health workforce and the COVID 19 pandemic response; 7) A lack of international cooperation, unity, and coordination in the pursuit of establishing global health equity; and 8) Lack of access to authorized and safe treatment and vaccine among other things. Despite these challenges, a monkeypox-free Nigeria is possible. To this end, a safe and effective immunization of the public, as with smallpox, polio and yellow fever, is the key to the future. Until, a safe and effective vaccine becomes readily available, control and prevention lies largely on non-pharmaceutical intervention measures.
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