大鼠原位肿瘤肠癌的化疗研究。

Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology Pub Date : 1978-08-24 DOI:10.1007/BF00284097

F Sych, M Habs, D Schmähl

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引用次数: 11

摘要

三种不同的化学致癌物诱发大鼠肠道肿瘤。只有1,2-二甲基肼诱导的肿瘤对阿霉素、甲氨蝶呤、5-氟尿嘧啶和环磷酰胺联合化疗有轻微反应。同样的治疗在n -甲基-n '-硝基-n -亚硝基胍或乙酰氧基甲基-甲基亚硝胺诱导的肿瘤中失败。本文还讨论了这些结果以及原位肿瘤化疗与实验和临床观察的可比性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Chemotherapy studies in autochthonous rat tumors intestinal cancer.

Intestinal tumors in rats were induced by three different chemical carcinogens. Only tumors induced by 1,2-dimethylhydrazine responded slightly to combination chemotherapy of Adriamycin, Methotrexate, 5-Fluorouracil, and Cyclophosphamide. The same therapy failed in tumors induced by N-methyl-N'-nitro-N-nitroso-guanidine or acetoxymethyl-methyl-nitrosamine. These results and the comparability of chemotherapy in autochthonous tumors to experimental and clinical observations are discussed.

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Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology

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