1-氧丙基丙基亚硝胺(n -亚硝基-n -丙基-丙胺)对叙利亚仓鼠的致癌性。

Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology Pub Date : 1977-12-15 DOI:10.1007/BF00284295

J Althoff, C Grandjean, B Gold, R Runge

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摘要

研究了1-氧丙基丙基亚硝胺(1-OPPN)对叙利亚仓鼠的影响。皮下注射(s.c.)LD50为308 mg/kg b.w。大剂量1-OPPN一次性处理sc的动物出现皮下肉瘤和阴道乳头状瘤。终生每周注射sc导致注射部位肉瘤的高发生率。此外，1-OPPN具有全身性作用。肿瘤发生在鼻腔、喉部、气管、肺、前胃和阴道。这些结果与其他DPN衍生物在α位置上取代的结果相联系进行了讨论。

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Carcinogenicity of 1-oxopropylpropylnitrosamine (N-nitroso-N-propyl-proprionamide) in Syrian hamsters.

The effect of 1-oxopropylpropylnitrosamine (1-OPPN) was examined in Syrian hamsters. The subcutaneous (s.c.) LD50 was 308 mg/kg b.w. Animals treated s.c. once with a high dose of 1-OPPN had subcutaneous sarcomas and vaginal papillomas. Weekly s.c. injections for life led to high incidences of sarcomas at the injection site. In addition, 1-OPPN had a systemic effect. Neoplasms developed in the nasal cavity, larynx, trachea, lungs forestomach, and vagina. The results are discussed in connection with those found with other DPN derivatives substituted in the alpha-position.

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Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology

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