酒精性肝病(马洛里体)和培养的肝癌细胞中透明物质中的中间纤维。

Virchows Archiv. B, Cell pathology Pub Date : 1979-02-06 DOI:10.1007/BF02899367

I Virtanen, V P Lehto, P Kurki, A Miettinen, E Linder, S Stenman

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引用次数: 13

摘要

针对细胞骨架中间(10 nm)细丝的特异性抗体，既可与酒精性肝病(Mallory小体)中的透明沉积反应，也可与培养的肝癌细胞的核周透明物质反应，该物质被用作体外透明物质形成的模型。我们的研究结果表明，中间纤维的紊乱和积累是酒精性肝损伤发病机制的重要步骤。

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Intermediate filaments in hyaline material in alcoholic liver disease (Mallory bodies) and in cultured hepatoma cells.

Antibodies specific for cytoskeletal intermediate (10 nm) filaments reacted both with the hyaline deposits in alcoholic liver disease (Mallory bodies) and with perinuclear hyaline material of cultured hepatoma cells used as a model for hyaline formation in vitro. Our results suggest that disorganization and accumulation of intermediate filaments is an important step in the pathogenesis of alcoholic liver injury.

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Virchows Archiv. B, Cell pathology

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