从锯蝇(Lophyrotoma interrupta, Lophyrotoma)幼虫中提取的一种新的毒肽。

Lloydia Pub Date : 1977-03-01

P B Oelrichs, P J Vallely, J K Macleod, J Cable, D E Kiely, R E Summons

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引用次数: 0

摘要

采用溶剂萃取、透析、聚酰胺吸附、DEAE纤维素离子交换层析和硅胶G层析等方法从锯蝇(Lophyrotomin, Lophyrotomin)幼虫中分离得到一种新的毒性八肽。根据化学方法、pmr和质谱的证据，提出了一个部分结构。Lophyrotomin对小鼠的腹腔内LD50约为2mg /kg。

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Lophyrotomin, a new toxic octapeptide from the larvae of sawfly, Lophyrotoma interrupta.

Lophyrotomin, a new toxic octapeptide, has been isolated from sawfly (Lophyrotoma interrupta) larvae using solvent extraction, dialysis, adsorption on polyamide, ion exchange chromatography on DEAE cellulose and silica gel G chromatography. On the basis of evidence from chemical methods, pmr and mass spectrometry, a partial structure is proposed. Lophyrotomin has an approximate intraperitoneal LD50 of 2 mg/kg for mice.

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Lloydia

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