中性粒细胞与淋巴细胞比率和中性粒细胞与单核细胞比率在严重脑外伤中的预测价值:回顾性队列。

IF 1.3 4区 医学 Q4 CLINICAL NEUROLOGY
Journal of neurosurgical sciences Pub Date : 2024-10-01 Epub Date: 2023-03-08 DOI:10.23736/S0390-5616.23.05877-0
Luiz F Matias, Murilo D Pimentel, Mateus F Medeiros, Franciani R Rocha, Marcelo V Gambetta, Samantha C Lopes
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引用次数: 0

摘要

背景:中性粒细胞-淋巴细胞比值(NLR)、血小板-淋巴细胞比值(PLR)、淋巴细胞-单核细胞比值(LMR)、中性粒细胞-单核细胞比值(NMR)和全身免疫炎症指数(SII)与肿瘤疾病、心血管疾病、感染性/炎症性疾病、内分泌疾病、肺部疾病和脑损伤的临床结果相关。在此,我们研究了其与严重脑外伤患者住院死亡率的关系:我们回顾性分析了 2015 年 1 月至 2020 年 12 月期间在我科接受治疗的严重创伤性脑损伤(sTBI)患者的临床数据。收集了入院至第 3 天的 NLR、PLR、NMR、LMR 和 SII 数据以及其他相关指标。分析了血液学比率与院内死亡率之间的关系:研究共纳入96名患者,住院死亡率为40.6%(N=39)。入院时(D0)、NLR 第 1 天(D1)、NLR 第 2 天(D2)、NLR 第 3 天(D3)、NMR 第 1 天(D1)和 NMR 第 2 天(D2)的水平在院内死亡患者中仍显著较高(分别为 P=0.030; P=0.038; P=0.016; P=0.048; P=0.046 和 P=0.001)。多变量逻辑分析显示,入院时较高的NLR值和第2天的NMR值与院内死亡率相关(OR=1.120,P=0.037;OR=1.307,P=0.004)。受试者操作特征曲线(ROC)分析显示,根据最佳阈值,入院时的NLR预测院内死亡率的灵敏度为59.0%,特异度为66.7%(曲线下面积为0.630,P=0.031,Youden指数为0.26),第2天的NMR预测院内死亡率的灵敏度为67.7%,特异度为70.4%(曲线下面积为0.719,P=0.001,Youden指数为0.38):我们的分析表明,入院时较高的 NLR 水平和第 2 天的 NMR 是 sTBI 患者院内死亡率的独立预测因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Predictive value of neutrophil-to-lymphocyte ratio and neutrophil-to-monocyte ratio in severe traumatic brain injury: a retrospective cohort.

Background: The neutrophil-lymphocyte ratio (NLR), the platelet-lymphocyte ratio (PLR), the lymphocyte-monocyte ratio (LMR), the neutrophil-monocyte ratio (NMR) and the systemic immune inflammation index (SII) are associated with clinical outcomes in oncological diseases, cardiovascular diseases, infectious / inflammatory diseases, endocrinological, pulmonary and brain injuries. Here, we investigate its association with hospital mortality in patients with severe traumatic brain injury.

Methods: We retrospectively reviewed clinical data from patients with severe traumatic brain injury (sTBI) who were treated in our department between January 2015 and December 2020. NLR, PLR, NMR, LMR and SII data were collected between admission and day 3, as well as other indicators related. The relationship between hematological ratios and in-hospital mortality were analyzed.

Results: A total of 96 patients were included in study, hospital mortality was 40.6% (N.=39). The levels of NLR on admission (D0), NLR day 1 (D1), NLR day 2 (D2), NLR day 3 (D3), NMR day 1 (D1) and NMR day (2) remained significantly higher in patients with death intra-hospital (P=0.030; P=0.038; P=0.016; P=0.048; P=0.046 and P=0.001, respectively). Multivariate logistic analysis showed that higher NLR values at admission and day 2 NMR were associated with in-hospital mortality (OR=1.120, P=0.037; and OR=1.307, P=0.004, respectively). Analysis of the recipient operating characteristic (ROC) curve showed that the NLR on admission had a sensitivity of 59.0% and a specificity of 66.7% (area under the curve 0.630, P=0.031, Youden's Index 0.26) and the NMR of day 2 had a sensitivity of 67.7% and a specificity of 70.4% (area under the curve 0.719, P=0.001, Youden's index 0.38) to predict mortality intra-hospital based on the best threshold.

Conclusions: Our analysis indicates that higher NLR levels on admission and day 2 NMR are independent predictors of in-hospital mortality in patients with sTBI.

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来源期刊
Journal of neurosurgical sciences
Journal of neurosurgical sciences CLINICAL NEUROLOGY-SURGERY
CiteScore
3.00
自引率
5.30%
发文量
202
审稿时长
>12 weeks
期刊介绍: The Journal of Neurosurgical Sciences publishes scientific papers on neurosurgery and related subjects (electroencephalography, neurophysiology, neurochemistry, neuropathology, stereotaxy, neuroanatomy, neuroradiology, etc.). Manuscripts may be submitted in the form of ditorials, original articles, review articles, special articles, letters to the Editor and guidelines. The journal aims to provide its readers with papers of the highest quality and impact through a process of careful peer review and editorial work.
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