药物学中的4D打印

IF 5.2 2区 医学 Q1 PHARMACOLOGY & PHARMACY
Andrea Gazzaniga, Anastasia Foppoli, Matteo Cerea, Luca Palugan, Micol Cirilli, Saliha Moutaharrik, Alice Melocchi, Alessandra Maroni
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引用次数: 10

摘要

四维打印(4DP)是一个新兴的研究课题。它涉及使用智能材料对物品进行三维打印(3DP),这些物品在生产后,当暴露于适当的外部非机械刺激(湿度、电场或磁场、紫外线、温度、pH或离子组成)时,会随着时间的推移以程序化的方式改变其形状。在4D打印设备的性能中,时间是第四维度。早在3D打印出现之前,4D智能结构在科学文献中就已经存在多年,形状进化和自组装的概念已经应用于纳米、微观和宏观水平的药物递送。新词“4DP”是由麻省理工学院的蒂比特于2013年创造的,他还展示了4D打印物体的最早例子。从那时起,智能材料经常与增材制造相结合,这使得复杂形状的生产很容易实现:超越3DP,4D打印物品不再是静态物体。4DP的原料主要有两类:形状记忆聚合物(SMPs)和形状变形水凝胶(SMHs)。原则上,所有类型的3D打印机都可以用于4DP。在这篇文章中,综述了生物医学领域中使用的系统的例子,如支架和支架,以及药物递送,特别强调了用于膀胱和胃中滞留的留置装置。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Towards 4D printing in pharmaceutics

Towards 4D printing in pharmaceutics

Four-dimensional printing (4DP) is emerging as an innovative research topic. It involves the use of smart materials for three-dimensional printing (3DP) of items that change their shape after production, in a programmed way over time, when exposed to appropriate external non-mechanical stimuli (moisture, electric or magnetic fields, UV, temperature, pH or ion composition). In the performance of 4D printed devices, time is involved as the 4th dimension. 4D smart structures have been known for many years in the scientific literature, well before the advent of 3D printing, and the concepts of shape evolution as well as self-assembly have been applied to drug delivery at the nano-, micro- and macro-scale levels. The neologism “4DP” was coined by Tibbits, Massachusetts Institute of Technology, in 2013, who also showed the earliest examples of 4D printed objects. Since then, smart materials have often been combined with additive manufacturing, which makes production of complex shapes easy to achieve: going beyond 3DP, 4D printed items are no static objects. Two main categories of raw materials have been employed for 4DP: shape memory polymers (SMPs) and shape morphing hydrogels (SMHs). In principle, all types of 3D printers could be used for 4DP. In this article, examples of systems for use in the biomedical field, such as stents and scaffolds, and in drug delivery are reviewed, with special emphasis on indwelling devices for retention in the urinary bladder and in the stomach.

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来源期刊
International Journal of Pharmaceutics: X
International Journal of Pharmaceutics: X Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
6.60
自引率
0.00%
发文量
32
审稿时长
24 days
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