基于41个Y-STR位点的中国西南藏缅语系拉祜族群体遗传多态性及系统发育特征

IF 1.2 4区 医学 Q2 ANTHROPOLOGY
Chongchong Xu, Wei Wei, Mingxin Zuo, Wu Zuo, Kuan Li, Xinqing Lian, Shixu Wang, Xuemei Zhou, Xiufeng Zhang, Shurong Zhong
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引用次数: 1

摘要

背景:男性性连锁y染色体短串联重复序列(Y-STRs)已广泛应用于法医案件和群体遗传学研究。目前,中国拉祜族人群的法医相关Y-STR数据仍然知之甚少。目的:丰富中国少数民族人群的Y-STR数据,探讨其与其他已报道人群的系统发育关系。对象和方法:对299例无亲缘关系拉祜族健康男性进行41个Y-STR基因座遗传多态性分析。系统发育分析采用多维尺度分析和邻居连接系统发育树构建。结果:41个Y-STR位点共检测到379个等位基因。等位基因频率范围为0.0033 ~ 0.9666。遗传多样性值为0.0653 ~ 0.9072。在299个个体中共观察到41个Y-STR基因座的254个不同的单倍型。单倍型多样性、单倍型匹配概率和辨别能力分别为0.9987、0.0047和0.8495。系统发育分析表明,藏缅语系拉祜族与云南彝族有密切的亲缘关系。结论:本研究的单倍型数据可丰富中国少数民族人群的法医数据库,对群体遗传学和法医DNA应用具有重要意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Genetic polymorphisms and phylogenetic characteristics of Tibeto-Burman-speaking Lahu population from southwest China based on 41 Y-STR loci.

Background: Male sex-linked Y-chromosome short tandem repeats (Y-STRs) have been widely used in forensic cases and population genetics research. At present, the forensic-related Y-STR data in the Chinese Lahu population are still poorly understood.

Aim: To enrich the available Y-STR data of this Chinese minority population and investigate its phylogenetic relationships with other reported populations.

Subjects and methods: The genetic polymorphisms of 41 Y-STR loci were analysed in 299 unrelated healthy Lahu male individuals from Southwest China. Phylogenetic analyses were performed by multidimensional scaling analysis and neighbor-joining phylogenetic tree construction.

Results: A total of 379 alleles were observed at the 41 Y-STR loci. The allele frequencies ranged from 0.0033 to 0.9666. The genetic diversity values ranged from 0.0653 to 0.9072. A total of 254 different haplotypes of the 41 Y-STR loci were observed in 299 individuals. The values of haplotype diversity, haplotype match probability, and discrimination capacity were 0.9987, 0.0047, and 0.8495, respectively. The phylogenetic analysis indicated that the Tibeto-Burman-speaking Lahu population showed a close genetic relationship with the Yunnan Yi population.

Conclusions: The haplotype data of the present study can enrich the forensic databases of this Chinese minority population and will be useful for population genetics and forensic DNA application.

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来源期刊
Annals of Human Biology
Annals of Human Biology 生物-公共卫生、环境卫生与职业卫生
CiteScore
3.40
自引率
5.90%
发文量
46
审稿时长
1 months
期刊介绍: Annals of Human Biology is an international, peer-reviewed journal published six times a year in electronic format. The journal reports investigations on the nature, development and causes of human variation, embracing the disciplines of human growth and development, human genetics, physical and biological anthropology, demography, environmental physiology, ecology, epidemiology and global health and ageing research.
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