以精神症状为表现的难治性糖尿病舞蹈病1例

IF 0.6 4区医学 Q4 CLINICAL NEUROLOGY

Neurocase Pub Date : 2022-10-01 DOI:10.1080/13554794.2022.2145906

Tsubasa Miyauchi, Masami Yoshii, Takeo Oshima, Ken Tomotsune, Kazuhiro Tomiyasu

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引用次数: 1

摘要

我们报告一例69岁男性糖尿病舞蹈病治疗难治性表现精神症状。右侧舞蹈病持续3个月，对糖尿病控制或氟哌啶醇、苯二氮卓类药物治疗无效。仅给予噻必利有效。磁共振光谱和多巴胺转运体-单光子发射计算机断层扫描显示，纹状体持续缺血可导致多巴胺转运体表达受损，从而导致间接通路恶化。噻必利抑制多巴胺D2受体，从而恢复间接通路的功能，从而改善糖尿病舞蹈病。

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Treatment-resistant diabetic chorea manifesting with psychiatric symptoms: a case report.

We report a case of a 69-year-old man with treatment-resistant diabetic chorea presenting psychiatric symptoms. The right chorea lasted for 3 months and was refractory to control of diabetes mellitus or administration of haloperidol and benzodiazepines. Only administration of tiapride was efficacious. Magnetic resonance spectrometry and dopamine transporter-single photon emission computed tomography suggested that sustained ischemia at the striatum may lead to impaired expression of dopamine transporters, thereby resulting in deterioration in the indirect pathway. Tiapride inhibited dopamine D2 receptors, thereby restoring the function of the indirect pathway and resulting in improvement of diabetic chorea.

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来源期刊

Neurocase 医学-精神病学

CiteScore

1.40

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Neurocase is a rapid response journal of case studies and innovative group studies in neuropsychology, neuropsychiatry and behavioral neurology that speak to the neural basis of cognition. Four types of manuscript are considered for publication: single case investigations that bear directly on issues of relevance to theoretical issues or brain-behavior relationships; group studies of subjects with brain dysfunction that address issues relevant to the understanding of human cognition; reviews of important topics in the domains of neuropsychology, neuropsychiatry and behavioral neurology; and brief reports (up to 2500 words) that replicate previous reports dealing with issues of considerable significance. Of particular interest are investigations that include precise anatomical localization of lesions or neural activity via imaging or other techniques, as well as studies of patients with neurodegenerative diseases, since these diseases are becoming more common as our population ages. Topic reviews are included in most issues.