唐氏综合症的产前和产后药物治疗:预防或改善神经发育和神经退行性疾病的研究。

IF 11.2 1区 医学 Q1 PHARMACOLOGY & PHARMACY
Renata Bartesaghi, Stefano Vicari, William C Mobley
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引用次数: 4

摘要

患有唐氏综合症(DS)(21号染色体三体)的儿童和成人通常会受到认知功能障碍和行为挑战的影响,老年人则会患上阿尔茨海默病。没有经过证实的治疗方法专门针对这些认知或行为改变。然而,建立啮齿动物模型和人类细胞模型的进展有望支持此类治疗的发展。研究议程强调识别过度表达的基因,这些基因明显导致模型系统中的认知和行为异常,这是一个合理的下一步。这些基因的正常表达可能会开启一个成功治疗的时代,适用于DS患者的整个生命周期。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Prenatal and Postnatal Pharmacotherapy in Down Syndrome: The Search to Prevent or Ameliorate Neurodevelopmental and Neurodegenerative Disorders.

Prenatal and Postnatal Pharmacotherapy in Down Syndrome: The Search to Prevent or Ameliorate Neurodevelopmental and Neurodegenerative Disorders.

Those with Down syndrome (DS)-trisomy for chromosome 21-are routinely impacted by cognitive dysfunction and behavioral challenges in children and adults and Alzheimer's disease in older adults. No proven treatments specifically address these cognitive or behavioral changes. However, advances in the establishment of rodent models and human cell models promise to support development of such treatments. A research agenda that emphasizes the identification of overexpressed genes that contribute demonstrably to abnormalities in cognition and behavior in model systems constitutes a rational next step. Normalizing expression of such genes may usher in an era of successful treatments applicable across the life span for those with DS.

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来源期刊
CiteScore
27.80
自引率
0.00%
发文量
53
期刊介绍: Since 1961, the Annual Review of Pharmacology and Toxicology has been a comprehensive resource covering significant developments in pharmacology and toxicology. The journal encompasses various aspects, including receptors, transporters, enzymes, chemical agents, drug development science, and systems like the immune, nervous, gastrointestinal, cardiovascular, endocrine, and pulmonary systems. Special topics are also featured in this annual review.
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