Natalie Rasmussen Mandolfo, Ann M Berger, Leeza Struwe, Kathleen M Hanna, Whitney Goldner, Kelsey Klute, Sean Langenfeld, Marilyn Hammer
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Chi-square (χ<sup>2</sup>), Fisher's exact, and Mann-Whitney U tests were used for the analyses.</p><p><strong>Results: </strong>Among the sample of 165 patients with stage II-III colon cancer, those with T2D had higher glycemic variability compared to patients without T2D (<i>p</i> < .001), with values within 1 month following surgery (SD <i>=</i> 44.69 mg/dL, CV <i>=</i> 27.4%) vs (SD <i>=</i> 20.55 mg/dL, CV <i>=</i> 17.53%); and within 1 year following surgery (SD <i>=</i> 45.04 mg/dL, CV <i>=</i> 29.04%) vs (SD <i>=</i> 21.36 mg/dL, CV <i>=</i> 18.6%). Associations were found between lower body mass index and higher glycemic variability (i.e., SD [r <i>=</i> -.413, <i>p <</i> .05] and CV [r <i>=</i> -.481, <i>p <</i> .01]) within 1 month following surgery in patients with T2D. Higher preoperative glucose was associated with higher glycemic variability (i.e., SD r <i>=</i> .448, <i>p <</i> .01) within 1 year in patients with T2D. Demographic and clinical characteristics were weakly associated with glycemic variability in patients without T2D.</p><p><strong>Conclusions: </strong>Patients with stage II-III colon cancer with T2D experienced higher glycemic variability within 1 month and within 1 year following surgery compared to those without T2D. Associations between glycemic variability and demographic and clinical characteristics differed by T2D status. Further research in prospective studies is warranted.</p>","PeriodicalId":8997,"journal":{"name":"Biological research for nursing","volume":"24 1","pages":"64-74"},"PeriodicalIF":1.9000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248290/pdf/10.1177_10998004211035184.pdf","citationCount":"0","resultStr":"{\"title\":\"Glycemic Variability Within 1 Year Following Surgery for Stage II-III Colon Cancer.\",\"authors\":\"Natalie Rasmussen Mandolfo, Ann M Berger, Leeza Struwe, Kathleen M Hanna, Whitney Goldner, Kelsey Klute, Sean Langenfeld, Marilyn Hammer\",\"doi\":\"10.1177/10998004211035184\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To examine glycemic variability within 1 month and 1 year following surgery among adult patients, with and without Type 2 Diabetes (T2D), treated for stage II-III colon cancer.</p><p><strong>Method: </strong>A retrospective analysis of electronic health record data was conducted. Glycemic variability (i.e., standard deviation [SD] and coefficient of variation [CV] of <u>></u> 2 blood glucose measures) was assessed within 1 month and within 1 year following colon surgery. Chi-square (χ<sup>2</sup>), Fisher's exact, and Mann-Whitney U tests were used for the analyses.</p><p><strong>Results: </strong>Among the sample of 165 patients with stage II-III colon cancer, those with T2D had higher glycemic variability compared to patients without T2D (<i>p</i> < .001), with values within 1 month following surgery (SD <i>=</i> 44.69 mg/dL, CV <i>=</i> 27.4%) vs (SD <i>=</i> 20.55 mg/dL, CV <i>=</i> 17.53%); and within 1 year following surgery (SD <i>=</i> 45.04 mg/dL, CV <i>=</i> 29.04%) vs (SD <i>=</i> 21.36 mg/dL, CV <i>=</i> 18.6%). Associations were found between lower body mass index and higher glycemic variability (i.e., SD [r <i>=</i> -.413, <i>p <</i> .05] and CV [r <i>=</i> -.481, <i>p <</i> .01]) within 1 month following surgery in patients with T2D. Higher preoperative glucose was associated with higher glycemic variability (i.e., SD r <i>=</i> .448, <i>p <</i> .01) within 1 year in patients with T2D. Demographic and clinical characteristics were weakly associated with glycemic variability in patients without T2D.</p><p><strong>Conclusions: </strong>Patients with stage II-III colon cancer with T2D experienced higher glycemic variability within 1 month and within 1 year following surgery compared to those without T2D. Associations between glycemic variability and demographic and clinical characteristics differed by T2D status. 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引用次数: 0
摘要
目的:研究II-III期结肠癌治疗的2型糖尿病(T2D)成年患者术后1个月和1年内的血糖变异性。方法:对电子病历资料进行回顾性分析。在结肠手术后1个月内和1年内评估血糖变异性(即> 2项血糖测量的标准差[SD]和变异系数[CV])。采用χ2、Fisher精确检验和Mann-Whitney U检验进行分析。结果:在165例II-III期结肠癌患者样本中，T2D患者的血糖变异性高于无T2D患者(p < 0.001)，其值在术后1个月内(SD = 44.69 mg/dL, CV = 27.4%) vs (SD = 20.55 mg/dL, CV = 17.53%);术后1年内(SD = 45.04 mg/dL, CV = 29.04%) vs (SD = 21.36 mg/dL, CV = 18.6%)。发现较低的体重指数与较高的血糖变异性(即SD [r = -])之间存在关联。413, p .05]和CV [r = -。[481, p .01])。术前较高的血糖水平与T2D患者1年内较高的血糖变异性相关(即标准差r = 0.448, p .01)。非t2dm患者的人口学和临床特征与血糖变异性相关性较弱。结论:II-III期结肠癌合并T2D患者术后1个月和1年内血糖变异性高于未合并T2D的患者。血糖变异性与人口学和临床特征之间的关系因糖尿病状态而异。进一步的前瞻性研究是必要的。
Glycemic Variability Within 1 Year Following Surgery for Stage II-III Colon Cancer.
Objective: To examine glycemic variability within 1 month and 1 year following surgery among adult patients, with and without Type 2 Diabetes (T2D), treated for stage II-III colon cancer.
Method: A retrospective analysis of electronic health record data was conducted. Glycemic variability (i.e., standard deviation [SD] and coefficient of variation [CV] of > 2 blood glucose measures) was assessed within 1 month and within 1 year following colon surgery. Chi-square (χ2), Fisher's exact, and Mann-Whitney U tests were used for the analyses.
Results: Among the sample of 165 patients with stage II-III colon cancer, those with T2D had higher glycemic variability compared to patients without T2D (p < .001), with values within 1 month following surgery (SD = 44.69 mg/dL, CV = 27.4%) vs (SD = 20.55 mg/dL, CV = 17.53%); and within 1 year following surgery (SD = 45.04 mg/dL, CV = 29.04%) vs (SD = 21.36 mg/dL, CV = 18.6%). Associations were found between lower body mass index and higher glycemic variability (i.e., SD [r = -.413, p < .05] and CV [r = -.481, p < .01]) within 1 month following surgery in patients with T2D. Higher preoperative glucose was associated with higher glycemic variability (i.e., SD r = .448, p < .01) within 1 year in patients with T2D. Demographic and clinical characteristics were weakly associated with glycemic variability in patients without T2D.
Conclusions: Patients with stage II-III colon cancer with T2D experienced higher glycemic variability within 1 month and within 1 year following surgery compared to those without T2D. Associations between glycemic variability and demographic and clinical characteristics differed by T2D status. Further research in prospective studies is warranted.
期刊介绍：
Biological Research For Nursing (BRN) is a peer-reviewed quarterly journal that helps nurse researchers, educators, and practitioners integrate information from many basic disciplines; biology, physiology, chemistry, health policy, business, engineering, education, communication and the social sciences into nursing research, theory and clinical practice. This journal is a member of the Committee on Publication Ethics (COPE)
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