[擦除素和G3139对慢性酒精中毒大鼠肝脏线粒体的影响]。

Q3 Biochemistry, Genetics and Molecular Biology

Biomeditsinskaya khimiya Pub Date : 2023-02-01 DOI:10.18097/PBMC20236901062

Yu L Baburina, A I Zvyagina, I V Odinokova, O V Krestinina

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引用次数: 0

摘要

在慢性酒精中毒大鼠肝脏线粒体中，研究了VDAC通道调节剂G3139和erastin对线粒体通透性过渡孔(mPTP)功能的影响以及参与mPTP调节的蛋白质(VDAC、CNPase和TSPO)含量的变化。结果表明，乙醇处理的大鼠线粒体对mPTP的诱导更为敏感。此外，乙醇诱导mPTP调节蛋白表达的变化。G3139和erastin也能够影响所研究的线粒体参数，并且与对照大鼠的线粒体相比，它们在乙醇处理大鼠的肝脏线粒体中的作用增强。我们假设本研究的结果可能有助于阐明乙醇对线粒体的慢性作用机制，并有助于开发治疗乙醇相关疾病后果的新治疗策略。

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[Effect of erastin and G3139 on rat liver mitochondria in chronic alcoholic intoxication].

The effect of modulators of VDAC channels - G3139 and erastin on the mitochondrial permeability transition pore (mPTP) functioning and changes in the content of proteins involved in regulation of mPTP (VDAC, CNPase, and TSPO) has been investigated in liver mitochondria of rats with chronic alcohol intoxication. It was shown that the mitochondria of rats treated with ethanol were more sensitive to mPTP induction. Moreover, ethanol induced changes in the expression of mPTP regulator proteins. G3139 and erastin were also able to influence the studied mitochondrial parameters, and they increased their effect in the liver mitochondria of rats treated with ethanol, as compared to the mitochondria of control rats. We hypothesize that the results of this study may help to elucidate the mechanisms of chronic action of ethanol on mitochondria and contribute to the development of new therapeutic strategies for treating the consequences of ethanol-related diseases.

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来源期刊

Biomeditsinskaya khimiya Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： The aim of the Russian-language journal "Biomeditsinskaya Khimiya" (Biomedical Chemistry) is to introduce the latest results obtained by scientists from Russia and other Republics of the Former Soviet Union. The Journal will cover all major areas of Biomedical chemistry, including neurochemistry, clinical chemistry, molecular biology of pathological processes, gene therapy, development of new drugs and their biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine etc. The Journal also publish review articles. All issues of journal usually contain invited reviews. Papers written in Russian contain abstract (in English).