Debora Stabile Romero Amais, Tainara Emilia Rodrigues da Silva, Beatriz Amstalden Barros, Juliana Gabriel Ribeiro de Andrade, Sofia Helena Valente de Lemos-Marini, Maricilda Palandi de Mello, Antonia Paula Marques- de-Faria, Tais Nitsch Mazzola, Mara Sanches Guaragna, Helena Fabbri-Scallet, Tarsis Antonio Paiva Vieira, Nilma Lucia Viguetti-Campos, Andre Moreno Morcillo, Olaf Hiort, Andrea Trevas Maciel-Guerra, Gil Guerra-Junior
{"title":"出生时体重和身高的性别二态性:基于性发育障碍的证据。","authors":"Debora Stabile Romero Amais, Tainara Emilia Rodrigues da Silva, Beatriz Amstalden Barros, Juliana Gabriel Ribeiro de Andrade, Sofia Helena Valente de Lemos-Marini, Maricilda Palandi de Mello, Antonia Paula Marques- de-Faria, Tais Nitsch Mazzola, Mara Sanches Guaragna, Helena Fabbri-Scallet, Tarsis Antonio Paiva Vieira, Nilma Lucia Viguetti-Campos, Andre Moreno Morcillo, Olaf Hiort, Andrea Trevas Maciel-Guerra, Gil Guerra-Junior","doi":"10.1080/03014460.2022.2134452","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Males have higher weight and length at birth than females.</p><p><strong>Aim: </strong>To verify the influence of the Y chromosome and the action of intrauterine androgens on weight and length at birth of children with Disorders of Sex Development (DSD).</p><p><strong>Subjects and methods: </strong>A cross-sectional and retrospective study. Patients with Turner syndrome (TS), complete (XX and XY), mixed (45,X/46,XY) and partial (XY) gonadal dysgenesis (GD), complete (CAIS) and partial (PAIS) androgen insensitivity syndromes and XX and XY congenital adrenal hyperplasia (CAH) were included. Weight and length at birth were evaluated.</p><p><strong>Results: </strong>Weight and length at birth were lower in TS and mixed GD when compared to XY and XX DSD cases. In turn, patients with increased androgen action (117 cases) had higher weight and length at birth when compared to those with absent (108 cases) and decreased (68 cases) production/action. In birthweight, there was a negative influence of the 45,X/46,XY karyotype and a positive influence of increased androgen and gestational age. In birth length, there was a negative influence of the 45,X and 45,X/46,XY karyotypes and also a positive influence of increased androgen and gestational age.</p><p><strong>Conclusions: </strong>The sex dimorphism of weight and length at birth could possibly be influenced by intrauterine androgenic action.</p>","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":null,"pages":null},"PeriodicalIF":1.2000,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Sex dimorphism of weight and length at birth: evidence based on disorders of sex development.\",\"authors\":\"Debora Stabile Romero Amais, Tainara Emilia Rodrigues da Silva, Beatriz Amstalden Barros, Juliana Gabriel Ribeiro de Andrade, Sofia Helena Valente de Lemos-Marini, Maricilda Palandi de Mello, Antonia Paula Marques- de-Faria, Tais Nitsch Mazzola, Mara Sanches Guaragna, Helena Fabbri-Scallet, Tarsis Antonio Paiva Vieira, Nilma Lucia Viguetti-Campos, Andre Moreno Morcillo, Olaf Hiort, Andrea Trevas Maciel-Guerra, Gil Guerra-Junior\",\"doi\":\"10.1080/03014460.2022.2134452\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Males have higher weight and length at birth than females.</p><p><strong>Aim: </strong>To verify the influence of the Y chromosome and the action of intrauterine androgens on weight and length at birth of children with Disorders of Sex Development (DSD).</p><p><strong>Subjects and methods: </strong>A cross-sectional and retrospective study. Patients with Turner syndrome (TS), complete (XX and XY), mixed (45,X/46,XY) and partial (XY) gonadal dysgenesis (GD), complete (CAIS) and partial (PAIS) androgen insensitivity syndromes and XX and XY congenital adrenal hyperplasia (CAH) were included. Weight and length at birth were evaluated.</p><p><strong>Results: </strong>Weight and length at birth were lower in TS and mixed GD when compared to XY and XX DSD cases. In turn, patients with increased androgen action (117 cases) had higher weight and length at birth when compared to those with absent (108 cases) and decreased (68 cases) production/action. In birthweight, there was a negative influence of the 45,X/46,XY karyotype and a positive influence of increased androgen and gestational age. In birth length, there was a negative influence of the 45,X and 45,X/46,XY karyotypes and also a positive influence of increased androgen and gestational age.</p><p><strong>Conclusions: </strong>The sex dimorphism of weight and length at birth could possibly be influenced by intrauterine androgenic action.</p>\",\"PeriodicalId\":50765,\"journal\":{\"name\":\"Annals of Human Biology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2022-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of Human Biology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/03014460.2022.2134452\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ANTHROPOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Human Biology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/03014460.2022.2134452","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ANTHROPOLOGY","Score":null,"Total":0}
Sex dimorphism of weight and length at birth: evidence based on disorders of sex development.
Background: Males have higher weight and length at birth than females.
Aim: To verify the influence of the Y chromosome and the action of intrauterine androgens on weight and length at birth of children with Disorders of Sex Development (DSD).
Subjects and methods: A cross-sectional and retrospective study. Patients with Turner syndrome (TS), complete (XX and XY), mixed (45,X/46,XY) and partial (XY) gonadal dysgenesis (GD), complete (CAIS) and partial (PAIS) androgen insensitivity syndromes and XX and XY congenital adrenal hyperplasia (CAH) were included. Weight and length at birth were evaluated.
Results: Weight and length at birth were lower in TS and mixed GD when compared to XY and XX DSD cases. In turn, patients with increased androgen action (117 cases) had higher weight and length at birth when compared to those with absent (108 cases) and decreased (68 cases) production/action. In birthweight, there was a negative influence of the 45,X/46,XY karyotype and a positive influence of increased androgen and gestational age. In birth length, there was a negative influence of the 45,X and 45,X/46,XY karyotypes and also a positive influence of increased androgen and gestational age.
Conclusions: The sex dimorphism of weight and length at birth could possibly be influenced by intrauterine androgenic action.
期刊介绍：
Annals of Human Biology is an international, peer-reviewed journal published six times a year in electronic format. The journal reports investigations on the nature, development and causes of human variation, embracing the disciplines of human growth and development, human genetics, physical and biological anthropology, demography, environmental physiology, ecology, epidemiology and global health and ageing research.
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