{"title":"工业皮革酶的计算建模和分子对接。","authors":"Nikita Sharma, Suneetha Vuppu","doi":"10.1007/s12033-023-00689-z","DOIUrl":null,"url":null,"abstract":"<p><p>Leather is one of the widely traded commodities globally. It is a strategically important sector for the economic and industrial development of the country. However, the leather industry is perceived as a highly polluting industry. It produces huge amounts of solid and liquid wastes, and if these wastes are not properly treated and disposed of, then it tends to deteriorate the quality of soil and water, as well as cause emanations of smell and noxious gases into the surrounding. The current paper provides information about industrial leather enzymes, primarily collagenase, tannase, and lecithinase. In this study, enzymes such as collagenase, tannase, and lecithinase had a pivotal role in leather industries and their action in the bioremediation of leather effluents was further analysed and docked with a diverse range of compounds (ligands), with an optimal binding affinity score was determined. All interactions between protein ligands were depicted, which will help us with future research. Furthermore, this method can be tested practically, and other parameters can be studied in the future. Further, applications of enzymes and their hydrolyse by-products have also been highlighted in a variety of industries, including the pharmaceutical, cosmetic, agricultural, medical, and food sectors. Subsequently, this finding provides an innovative and broader goal for various sectors in terms of sustainability, stabilisation, and identifying research gaps that can guide modern industries and research scientists.</p>","PeriodicalId":18865,"journal":{"name":"Molecular Biotechnology","volume":" ","pages":"2847-2865"},"PeriodicalIF":2.5000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Computational Modelling and Molecular Docking of Industrial Leather Enzymes.\",\"authors\":\"Nikita Sharma, Suneetha Vuppu\",\"doi\":\"10.1007/s12033-023-00689-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Leather is one of the widely traded commodities globally. It is a strategically important sector for the economic and industrial development of the country. However, the leather industry is perceived as a highly polluting industry. It produces huge amounts of solid and liquid wastes, and if these wastes are not properly treated and disposed of, then it tends to deteriorate the quality of soil and water, as well as cause emanations of smell and noxious gases into the surrounding. The current paper provides information about industrial leather enzymes, primarily collagenase, tannase, and lecithinase. In this study, enzymes such as collagenase, tannase, and lecithinase had a pivotal role in leather industries and their action in the bioremediation of leather effluents was further analysed and docked with a diverse range of compounds (ligands), with an optimal binding affinity score was determined. All interactions between protein ligands were depicted, which will help us with future research. Furthermore, this method can be tested practically, and other parameters can be studied in the future. Further, applications of enzymes and their hydrolyse by-products have also been highlighted in a variety of industries, including the pharmaceutical, cosmetic, agricultural, medical, and food sectors. Subsequently, this finding provides an innovative and broader goal for various sectors in terms of sustainability, stabilisation, and identifying research gaps that can guide modern industries and research scientists.</p>\",\"PeriodicalId\":18865,\"journal\":{\"name\":\"Molecular Biotechnology\",\"volume\":\" \",\"pages\":\"2847-2865\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecular Biotechnology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s12033-023-00689-z\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/2/20 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Biotechnology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12033-023-00689-z","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/2/20 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Computational Modelling and Molecular Docking of Industrial Leather Enzymes.
Leather is one of the widely traded commodities globally. It is a strategically important sector for the economic and industrial development of the country. However, the leather industry is perceived as a highly polluting industry. It produces huge amounts of solid and liquid wastes, and if these wastes are not properly treated and disposed of, then it tends to deteriorate the quality of soil and water, as well as cause emanations of smell and noxious gases into the surrounding. The current paper provides information about industrial leather enzymes, primarily collagenase, tannase, and lecithinase. In this study, enzymes such as collagenase, tannase, and lecithinase had a pivotal role in leather industries and their action in the bioremediation of leather effluents was further analysed and docked with a diverse range of compounds (ligands), with an optimal binding affinity score was determined. All interactions between protein ligands were depicted, which will help us with future research. Furthermore, this method can be tested practically, and other parameters can be studied in the future. Further, applications of enzymes and their hydrolyse by-products have also been highlighted in a variety of industries, including the pharmaceutical, cosmetic, agricultural, medical, and food sectors. Subsequently, this finding provides an innovative and broader goal for various sectors in terms of sustainability, stabilisation, and identifying research gaps that can guide modern industries and research scientists.
期刊介绍:
Molecular Biotechnology publishes original research papers on the application of molecular biology to both basic and applied research in the field of biotechnology. Particular areas of interest include the following: stability and expression of cloned gene products, cell transformation, gene cloning systems and the production of recombinant proteins, protein purification and analysis, transgenic species, developmental biology, mutation analysis, the applications of DNA fingerprinting, RNA interference, and PCR technology, microarray technology, proteomics, mass spectrometry, bioinformatics, plant molecular biology, microbial genetics, gene probes and the diagnosis of disease, pharmaceutical and health care products, therapeutic agents, vaccines, gene targeting, gene therapy, stem cell technology and tissue engineering, antisense technology, protein engineering and enzyme technology, monoclonal antibodies, glycobiology and glycomics, and agricultural biotechnology.