工业皮革酶的计算建模和分子对接。

IF 2.5 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Molecular Biotechnology Pub Date : 2025-08-01 Epub Date: 2023-02-20 DOI:10.1007/s12033-023-00689-z
Nikita Sharma, Suneetha Vuppu
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引用次数: 0

摘要

皮革是全球广泛交易的商品之一。它是对国家经济和工业发展具有重要战略意义的行业。然而,皮革业被视为高污染行业。它会产生大量的固体和液体废物,如果这些废物得不到适当的处理和处置,就会恶化土壤和水的质量,并向周围散发气味和有害气体。本文提供了有关工业皮革酶的信息,主要是胶原酶、单宁酶和卵磷脂酶。本研究进一步分析了胶原酶、单宁酶和卵磷脂酶等酶在皮革工业中的关键作用,以及它们在皮革废水生物修复中的作用,并与多种化合物(配体)进行了对接,确定了最佳结合亲和力分数。蛋白质配体之间的所有相互作用都被描绘出来,这将有助于我们今后的研究。此外,这种方法可以进行实际测试,将来还可以研究其他参数。此外,酶及其水解副产品在制药、化妆品、农业、医疗和食品等各行各业的应用也很突出。因此,这一发现为各行各业在可持续发展、稳定化方面提供了一个创新和更广泛的目标,并确定了可指导现代工业和研究科学家的研究差距。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Computational Modelling and Molecular Docking of Industrial Leather Enzymes.

Leather is one of the widely traded commodities globally. It is a strategically important sector for the economic and industrial development of the country. However, the leather industry is perceived as a highly polluting industry. It produces huge amounts of solid and liquid wastes, and if these wastes are not properly treated and disposed of, then it tends to deteriorate the quality of soil and water, as well as cause emanations of smell and noxious gases into the surrounding. The current paper provides information about industrial leather enzymes, primarily collagenase, tannase, and lecithinase. In this study, enzymes such as collagenase, tannase, and lecithinase had a pivotal role in leather industries and their action in the bioremediation of leather effluents was further analysed and docked with a diverse range of compounds (ligands), with an optimal binding affinity score was determined. All interactions between protein ligands were depicted, which will help us with future research. Furthermore, this method can be tested practically, and other parameters can be studied in the future. Further, applications of enzymes and their hydrolyse by-products have also been highlighted in a variety of industries, including the pharmaceutical, cosmetic, agricultural, medical, and food sectors. Subsequently, this finding provides an innovative and broader goal for various sectors in terms of sustainability, stabilisation, and identifying research gaps that can guide modern industries and research scientists.

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来源期刊
Molecular Biotechnology
Molecular Biotechnology 医学-生化与分子生物学
CiteScore
4.10
自引率
3.80%
发文量
165
审稿时长
6 months
期刊介绍: Molecular Biotechnology publishes original research papers on the application of molecular biology to both basic and applied research in the field of biotechnology. Particular areas of interest include the following: stability and expression of cloned gene products, cell transformation, gene cloning systems and the production of recombinant proteins, protein purification and analysis, transgenic species, developmental biology, mutation analysis, the applications of DNA fingerprinting, RNA interference, and PCR technology, microarray technology, proteomics, mass spectrometry, bioinformatics, plant molecular biology, microbial genetics, gene probes and the diagnosis of disease, pharmaceutical and health care products, therapeutic agents, vaccines, gene targeting, gene therapy, stem cell technology and tissue engineering, antisense technology, protein engineering and enzyme technology, monoclonal antibodies, glycobiology and glycomics, and agricultural biotechnology.
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