Ravindra Maradi, Vivek Joshi, Vaideki Balamurugan, Divya Susan Thomas, Manjunath B Goud
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The serum concentrations of antioxidants and minerals were determined to establish the impact of COVID-19 on antioxidants mechanism and nutrient status in COVID-19 patients.</p><p><strong>Results: </strong>The serum concentrations of GPX (10.36 ± 2.70 ≥ 5.82 ± 1.64 mKAT/L, p < 0.0001) and copper (2192.5 ± 449.8 ≥ 782.15 ± 106.5 µg/dL, p < 0.0001) were significantly greater, and zinc (34.78 ± 4.5 ≤ 81.07 ± 10.13 µg/dL, p < 0.0001) was significantly less, in the study group than in controls. The Pearson correlation between serum SOD and zinc was significant (r = 0.491, p < 0.0001) indicating the importance of zinc in maintaining and improving SOD activity. No significant correlations were observed between copper and SOD (r = -0.089) or iron and CAT (r = -0.027).</p><p><strong>Conclusion: </strong>Our study demonstrated the expected increase in oxidant-radical production during COVID-19 by estimating the altered concentrations of antioxidants and the minerals required to neutralize the elevated ROS. 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引用次数: 2
摘要
背景:COVID-19是由严重急性呼吸窘迫综合征冠状病毒2引起的。由于抗氧化机制如谷胱甘肽过氧化物酶或超氧化物歧化酶在病毒感染期间下调,因此在氧化-抗氧化系统中存在不平衡。在本研究中,我们旨在通过比较COVID-19患者和健康对照组中抗氧化剂和微量矿物质的浓度来确定COVID-19对抗氧化防御机制的影响。方法:本横断面分析研究涉及马尼帕尔大学卡斯图尔巴医院的200例患者。测定血清抗氧化剂和矿物质浓度,以确定COVID-19对COVID-19患者抗氧化剂机制和营养状况的影响。结果:研究组血清GPX(10.36±2.70≥5.82±1.64 mKAT/L, p < 0.0001)、铜(2192.5±449.8≥782.15±106.5µg/dL, p < 0.0001)浓度显著高于对照组,锌(34.78±4.5≤81.07±10.13µg/dL, p < 0.0001)浓度显著低于对照组。血清SOD与锌的Pearson相关性显著(r = 0.491, p < 0.0001),表明锌对维持和改善SOD活性的重要性。铜与SOD (r = -0.089)、铁与CAT (r = -0.027)之间无显著相关性。结论:我们的研究通过估计抗氧化剂和矿物质浓度的变化来中和升高的ROS,证明了COVID-19期间氧化自由基产生的预期增加。这一发现并不新颖,但为现有文献提供了补充,这些文献建议补充微量矿物质和抗氧化剂。
Importance of Microminerals for Maintaining Antioxidant Function After COVID-19-induced Oxidative Stress.
Background: COVID-19 is caused by the Severe Acute Respiratory Distress Syndrome Coronavirus 2. Since the antioxidant mechanisms such as glutathione peroxidase or superoxide dismutase are downregulated during infection by the virus, there is an imbalance in the oxidant-antioxidant system. In this study we aimed to identify the effect of COVID-19 on the antioxidant defense mechanism by comparing the concentrations of antioxidants and microminerals in COVID-19 patients and healthy controls.
Methods: This cross-sectional analytical study involved 200 patients at Kasturba Hospital, Manipal University. The serum concentrations of antioxidants and minerals were determined to establish the impact of COVID-19 on antioxidants mechanism and nutrient status in COVID-19 patients.
Results: The serum concentrations of GPX (10.36 ± 2.70 ≥ 5.82 ± 1.64 mKAT/L, p < 0.0001) and copper (2192.5 ± 449.8 ≥ 782.15 ± 106.5 µg/dL, p < 0.0001) were significantly greater, and zinc (34.78 ± 4.5 ≤ 81.07 ± 10.13 µg/dL, p < 0.0001) was significantly less, in the study group than in controls. The Pearson correlation between serum SOD and zinc was significant (r = 0.491, p < 0.0001) indicating the importance of zinc in maintaining and improving SOD activity. No significant correlations were observed between copper and SOD (r = -0.089) or iron and CAT (r = -0.027).
Conclusion: Our study demonstrated the expected increase in oxidant-radical production during COVID-19 by estimating the altered concentrations of antioxidants and the minerals required to neutralize the elevated ROS. This finding is not novel but adds to the existing literature, which recommends nutritional supplementation of microminerals and antioxidants.
期刊介绍:
The Reports of Biochemistry & Molecular Biology (RBMB) is the official journal of the Varastegan Institute for Medical Sciences and is dedicated to furthering international exchange of medical and biomedical science experience and opinion and a platform for worldwide dissemination. The RBMB is a medical journal that gives special emphasis to biochemical research and molecular biology studies. The Journal invites original and review articles, short communications, reports on experiments and clinical cases, and case reports containing new insights into any aspect of biochemistry and molecular biology that are not published or being considered for publication elsewhere. Publications are accepted in the form of reports of original research, brief communications, case reports, structured reviews, editorials, commentaries, views and perspectives, letters to authors, book reviews, resources, news, and event agenda.