19种膳食脂肪酸摄入与类风湿关节炎之间的关系:一项全国性调查的结果

IF 3
Ruijie Xie , Ya Zhang
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引用次数: 15

摘要

背景膳食脂肪酸摄入与类风湿性关节炎(RA)之间的关系尚不清楚,现有的研究仅集中在少数脂肪酸上。本研究调查了美国成年人摄入19种膳食脂肪酸与RA之间的关系。方法这项横断面研究使用了2010-2020年全国健康和营养检查调查(NHANES)中具有全国代表性的数据。采用多元线性回归模型、多元逻辑回归模型、平滑曲线拟合和二段线性回归模型,探讨了19种膳食脂肪酸摄入量与高敏C反应蛋白(Hs-CRP)和RA风险之间的关系。结果共纳入16530名参与者(1053名RA参与者)。十六烷酸和十八烷酸的摄入与较高的Hs-CRP水平显著相关,十六烷酸的摄入量与较高的RA风险显著相关,二十二碳六烯酸的摄入量与较低的RA风险明显相关。此外,总单不饱和脂肪酸(MUFA)摄入量与RA风险呈倒U型关系,拐点为15.77%。结论在19种膳食脂肪酸中,只有4个亚类与Hs-CRP或RA风险显著相关。MUFA和RA风险之间的倒U型关系可能为寻找RA的潜在预防策略提供见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between 19 dietary fatty acids intake and rheumatoid arthritis: Results of a nationwide survey

Background

The relationship between dietary fatty acid intakes and rheumatoid arthritis (RA) is unclear and the available studies have focused on only a few fatty acids. This study investigated the association between the intake of 19 dietary fatty acids and RA in U.S. adults.

Methods

This cross-sectional study using nationally representative data from the 2010-2020 National Health and Nutrition Examination Survey (NHANES). Multivariate linear regression model, multivariate logic regression models, smoothing curve fitting, and two-segment linear regression model were used to explore the relationships between 19 dietary fatty acids intakes with high-sensitivity C-reactive protein (Hs-CRP) and RA risk.

Results

A total of 16,530 participants were included (1053 participants with RA). Intake of hexadecanoic acid and octadecanoic acid were significantly associated with higher Hs-CRP levels, intake of hexadecenoic acid was significantly associated with higher RA risk, and intake of docosahexaenoic acid was significantly associated with lower RA risk. In addition, there was an inverted U-shaped relationship between total monounsaturated fatty acids (MUFAs) intake and RA risk, with the inflection point reached at 15.77% .

Conclusions

Among the 19 dietary fatty acids, only 4 subclasses were significantly associated with Hs-CRP or RA risk. The inverted U-shaped relationship between MUFAs and RA risk may provide insights to find potential prevention strategies for RA.

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来源期刊
Prostaglandins, leukotrienes, and essential fatty acids
Prostaglandins, leukotrienes, and essential fatty acids Clinical Biochemistry, Endocrinology, Diabetes and Metabolism
CiteScore
5.30
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0.00%
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审稿时长
64 days
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