上消化道症状患者自评抑郁症状与黏膜NF-κ B表达的关系

IF 2.3 4区 医学 Q2 PSYCHIATRY
Julia Staab, Lara Vonhören, Harald Schwörer, Thomas Meyer
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引用次数: 0

摘要

背景:先前的临床研究已经报道了在选定的胃炎患者样本中抑郁症状水平升高。本研究的目的是研究胃粘膜组织中表达的炎症特异性生物标志物与有上消化道症状的成年患者的情绪和焦虑症状的关系。方法:在这项单中心的观察性研究中,共有32名研究参与者被纳入,他们根据疑似胃炎的临床诊断进行常规的上镜诊断评估。所有参与者在胃镜检查前完成医院焦虑和抑郁量表(HADS)。活检切片采用免疫组化染色检测核因子κ B (NF-κ B)、髓过氧化物酶(MPO)和诱导型一氧化氮合酶(iNOS)的表达水平。结果:我们的研究结果证实,近一半的研究队列(n = 13;41%)表现出阳性的HADS抑郁评分高于临床相关的临界值≥8。回归模型显示,抑郁症状与上消化道活检中NF-κ B的表达水平显著正相关。结论:总之,我们的研究显示NF-κ B表达与胃炎患者临床相关抑郁症状之间存在显著关联,通过自评心理测量问卷进行评估。需要进一步的研究来证实这种关系,并确定所涉及的病理生理机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Association between self-rated depressive symptoms and mucosal expression of NF-κ B in patients with upper gastrointestinal symptoms.

Association between self-rated depressive symptoms and mucosal expression of NF-κ B in patients with upper gastrointestinal symptoms.

Association between self-rated depressive symptoms and mucosal expression of NF-κ B in patients with upper gastrointestinal symptoms.

Association between self-rated depressive symptoms and mucosal expression of NF-κ B in patients with upper gastrointestinal symptoms.

Background: Previous clinical studies have reported elevated levels of depressive symptoms in selected samples of patients with gastritis. The objective of this study was to examine the associations of specific biomarkers of inflammation expressed in mucosal tissue from the stomach with mood and anxiety symptoms in adult patients with upper gastrointestinal symptoms.

Methods: In this monocentric, observational study, a total of 32 study participants were included who were referred for a routine diagnostic upper endoscopic assessment based on the suspected clinical diagnosis of gastritis. All participants completed the Hospital Anxiety and Depression Scale (HADS) before undergoing gastroscopy. Immunohistochemical stainings from biopsy sections were performed to evaluate the expression level of nuclear factor kappa B (NF-κ B), myeloperoxidase (MPO) and inducible nitric oxide synthase (iNOS).

Results: Our findings confirmed that nearly half of the study cohort (n = 13; 41%) displayed positive HADS depression scores above the clinically relevant cut-off level of ≥ 8. Regression models demonstrated that depressive symptoms were significantly and positively associated with the expression level of NF-κ B in biopsies from the upper gastrointestinal tract.

Conclusions: In summary, our study showed a significant association between NF-κ B expression and clinically relevant depressive symptoms in patients with gastritis, as assessed by a self-rated psychometric questionnaire. Further investigations are needed to confirm this relationship and to identify the pathophysiological mechanisms involved.

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来源期刊
CiteScore
3.60
自引率
0.00%
发文量
23
审稿时长
18 weeks
期刊介绍: BioPsychoSocial Medicine is an open access, peer-reviewed online journal that encompasses all aspects of the interrelationships between the biological, psychological, social, and behavioral factors of health and illness. BioPsychoSocial Medicine is the official journal of the Japanese Society of Psychosomatic Medicine, and publishes research on psychosomatic disorders and diseases that are characterized by objective organic changes and/or functional changes that could be induced, progressed, aggravated, or exacerbated by psychological, social, and/or behavioral factors and their associated psychosomatic treatments.
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