Malgorzata Polacin, Tobias Hünermund, Oliver Müggler, Hatem Alkadhi, Sebastian Kozerke, Robert Manka
{"title":"患者特异性心脏磁共振特征跟踪方法用于伴发缺血性和非缺血性心脏病的疤痕检测。","authors":"Malgorzata Polacin, Tobias Hünermund, Oliver Müggler, Hatem Alkadhi, Sebastian Kozerke, Robert Manka","doi":"10.26502/fccm.92920297","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>This study investigated a patient-specific approach of using cardiac magnetic resonance (CMR) feature tracking for scar detection in a heterogenous patient group with chronic ischemic and non-ischemic heart disease.</p><p><strong>Methods: </strong>CMR exams of 89 patients with concomitant chronic ischemic and non-ischemic heart disease (IHD+) as well as 65 patients with ischemic scars only (IHD) were retrospectively evaluated. In all patients, global (GCS) and segmental circumferential strain (SCS) was derived from native cine images using a dedicated software (Segment CMR, Medviso). After calculation of patient-specific median GCS (GCS<sub>median</sub>), segmental values from GCS<sub>median</sub> percentage plots were correlated with corresponding myocardial segments in late gadolinium enhancement (LGE).</p><p><strong>Results: </strong>Overall GCS ranged between -3.5% to -19.8% and average GCS was lower in IHD+ than in IHD (p <0.05). In IHD, 19% of all myocardial segments were infarcted, in IHD+ 16.6%. Additionally, non-ischemic LGE was present in 6.7% of segments in IHD+. Correlation of GCS<sub>median</sub> percentage plots with corresponding LGE showed that presence of ischemic scar tissue in a myocardial segment was very likely below a cut-off of 39.5% GCS<sub>median</sub> (87.5% sensitivity, 86.3% specificity, AUC 0.907, 95% CI 0.875-0.938, p < 0.05).</p><p><strong>Conclusion: </strong>In patient-specific GCS<sub>median</sub> percentage plots calculated from native cine images, ischemic scar tissue can be suspected in myocardial segments below the threshold of 40% GCS<sub>median</sub> (sensitivity 88%, specificity 86%), even in a heterogenous patient cohort with ischemic and non-ischemic heart disease.</p>","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"6 6","pages":"542-549"},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937585/pdf/","citationCount":"0","resultStr":"{\"title\":\"Patient-Specific Cardiac Magnetic Resonance Feature Tracking Approach for Scar Detection in Concomitant Ischemic and Non-Ischemic Heart Disease.\",\"authors\":\"Malgorzata Polacin, Tobias Hünermund, Oliver Müggler, Hatem Alkadhi, Sebastian Kozerke, Robert Manka\",\"doi\":\"10.26502/fccm.92920297\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim: </strong>This study investigated a patient-specific approach of using cardiac magnetic resonance (CMR) feature tracking for scar detection in a heterogenous patient group with chronic ischemic and non-ischemic heart disease.</p><p><strong>Methods: </strong>CMR exams of 89 patients with concomitant chronic ischemic and non-ischemic heart disease (IHD+) as well as 65 patients with ischemic scars only (IHD) were retrospectively evaluated. In all patients, global (GCS) and segmental circumferential strain (SCS) was derived from native cine images using a dedicated software (Segment CMR, Medviso). After calculation of patient-specific median GCS (GCS<sub>median</sub>), segmental values from GCS<sub>median</sub> percentage plots were correlated with corresponding myocardial segments in late gadolinium enhancement (LGE).</p><p><strong>Results: </strong>Overall GCS ranged between -3.5% to -19.8% and average GCS was lower in IHD+ than in IHD (p <0.05). In IHD, 19% of all myocardial segments were infarcted, in IHD+ 16.6%. Additionally, non-ischemic LGE was present in 6.7% of segments in IHD+. Correlation of GCS<sub>median</sub> percentage plots with corresponding LGE showed that presence of ischemic scar tissue in a myocardial segment was very likely below a cut-off of 39.5% GCS<sub>median</sub> (87.5% sensitivity, 86.3% specificity, AUC 0.907, 95% CI 0.875-0.938, p < 0.05).</p><p><strong>Conclusion: </strong>In patient-specific GCS<sub>median</sub> percentage plots calculated from native cine images, ischemic scar tissue can be suspected in myocardial segments below the threshold of 40% GCS<sub>median</sub> (sensitivity 88%, specificity 86%), even in a heterogenous patient cohort with ischemic and non-ischemic heart disease.</p>\",\"PeriodicalId\":72523,\"journal\":{\"name\":\"Cardiology and cardiovascular medicine\",\"volume\":\"6 6\",\"pages\":\"542-549\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937585/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cardiology and cardiovascular medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.26502/fccm.92920297\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cardiology and cardiovascular medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.26502/fccm.92920297","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
目的:本研究探讨了一种使用心脏磁共振(CMR)特征跟踪检测慢性缺血性和非缺血性心脏病异质患者组疤痕的患者特异性方法。方法:回顾性分析89例合并慢性缺血性和非缺血性心脏病(IHD+)患者和65例单纯缺血性瘢痕(IHD)患者的CMR检查结果。在所有患者中，使用专用软件(片段CMR, Medviso)从原生电影图像中获得全局(GCS)和节段周向应变(SCS)。计算患者特异性中位GCS (GCSmedian)后，GCSmedian百分比图的段值与晚期钆增强(LGE)相应的心肌段相关。结果:总体GCS范围为-3.5%至-19.8%，IHD+组的平均GCS低于IHD组(相应LGE的p中位数百分比图显示心肌段存在缺血性瘢痕组织很可能低于GCS中位数39.5%的临界值(敏感性87.5%，特异性86.3%，AUC 0.907, 95% CI 0.875-0.938, p < 0.05)。结论:在原生电影图像计算的患者特异性GCSmedian百分比图中，即使在患有缺血性和非缺血性心脏病的异质患者队列中，在低于40% GCSmedian阈值的心肌段中也可以怀疑缺血性瘢痕组织(敏感性88%，特异性86%)。
Patient-Specific Cardiac Magnetic Resonance Feature Tracking Approach for Scar Detection in Concomitant Ischemic and Non-Ischemic Heart Disease.
Aim: This study investigated a patient-specific approach of using cardiac magnetic resonance (CMR) feature tracking for scar detection in a heterogenous patient group with chronic ischemic and non-ischemic heart disease.
Methods: CMR exams of 89 patients with concomitant chronic ischemic and non-ischemic heart disease (IHD+) as well as 65 patients with ischemic scars only (IHD) were retrospectively evaluated. In all patients, global (GCS) and segmental circumferential strain (SCS) was derived from native cine images using a dedicated software (Segment CMR, Medviso). After calculation of patient-specific median GCS (GCSmedian), segmental values from GCSmedian percentage plots were correlated with corresponding myocardial segments in late gadolinium enhancement (LGE).
Results: Overall GCS ranged between -3.5% to -19.8% and average GCS was lower in IHD+ than in IHD (p <0.05). In IHD, 19% of all myocardial segments were infarcted, in IHD+ 16.6%. Additionally, non-ischemic LGE was present in 6.7% of segments in IHD+. Correlation of GCSmedian percentage plots with corresponding LGE showed that presence of ischemic scar tissue in a myocardial segment was very likely below a cut-off of 39.5% GCSmedian (87.5% sensitivity, 86.3% specificity, AUC 0.907, 95% CI 0.875-0.938, p < 0.05).
Conclusion: In patient-specific GCSmedian percentage plots calculated from native cine images, ischemic scar tissue can be suspected in myocardial segments below the threshold of 40% GCSmedian (sensitivity 88%, specificity 86%), even in a heterogenous patient cohort with ischemic and non-ischemic heart disease.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
