松节油软膏治疗细菌性皮肤感染:随机、安慰剂对照、双盲临床试验。

IF 1.1 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE
Complementary Medicine Research Pub Date : 2023-01-01 Epub Date: 2022-11-23 DOI:10.1159/000528220
Joachim Fuchs-Algrim, Horst Lorenz, Christian Zimmermann, Nils Günnewich, Ilona Schwarzensteiner, Peter-Michael Kaiser, Hagen Tronnier
{"title":"松节油软膏治疗细菌性皮肤感染:随机、安慰剂对照、双盲临床试验。","authors":"Joachim Fuchs-Algrim, Horst Lorenz, Christian Zimmermann, Nils Günnewich, Ilona Schwarzensteiner, Peter-Michael Kaiser, Hagen Tronnier","doi":"10.1159/000528220","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Turpentine-containing substances are considered effective in treating cutaneous bacterial infections, but reliable clinical data are scant.</p><p><strong>Objective: </strong>We investigated the efficacy and safety of an ointment containing larch turpentine (from Larix decidua), eucalyptus oil (from Eucalyptus globulus), and turpentine oil (from Pinus pinaster) in outpatients with painful skin abscesses in a randomized, placebo-controlled, double-blind study.</p><p><strong>Intervention: </strong>116 outpatients with skin abscesses used verum or placebo for 10 days. Sum score of the patient's discomforts, changes in abscess size, rate of therapeutic success, and complete healing served as outcome parameters.</p><p><strong>Results: </strong>Fifty-four patients were treated with verum and 56 with placebo. According to the patient's discomfort sum score, patients in the verum group showed a better improvement compared to the placebo group (7.3 vs. 4.7; p = 0.024), and subjective assessment by the investigators revealed a higher treatment success rate after verum (70% vs. 48%; p = 0.021). Complete healing was documented in 67% of the patients receiving verum versus 46% in the placebo group (p = 0.037). There was a positive trend toward a larger decrease in the abscess sizes in the verum group compared to the placebo group (p = 0.07).</p><p><strong>Conclusion: </strong>The ointment studied is an effective and safe option for the treatment of bacterial skin diseases.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":"30 1","pages":"56-62"},"PeriodicalIF":1.1000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11078321/pdf/","citationCount":"0","resultStr":"{\"title\":\"Turpentine Ointment in Bacterial Skin Infections: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial.\",\"authors\":\"Joachim Fuchs-Algrim, Horst Lorenz, Christian Zimmermann, Nils Günnewich, Ilona Schwarzensteiner, Peter-Michael Kaiser, Hagen Tronnier\",\"doi\":\"10.1159/000528220\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Turpentine-containing substances are considered effective in treating cutaneous bacterial infections, but reliable clinical data are scant.</p><p><strong>Objective: </strong>We investigated the efficacy and safety of an ointment containing larch turpentine (from Larix decidua), eucalyptus oil (from Eucalyptus globulus), and turpentine oil (from Pinus pinaster) in outpatients with painful skin abscesses in a randomized, placebo-controlled, double-blind study.</p><p><strong>Intervention: </strong>116 outpatients with skin abscesses used verum or placebo for 10 days. Sum score of the patient's discomforts, changes in abscess size, rate of therapeutic success, and complete healing served as outcome parameters.</p><p><strong>Results: </strong>Fifty-four patients were treated with verum and 56 with placebo. According to the patient's discomfort sum score, patients in the verum group showed a better improvement compared to the placebo group (7.3 vs. 4.7; p = 0.024), and subjective assessment by the investigators revealed a higher treatment success rate after verum (70% vs. 48%; p = 0.021). Complete healing was documented in 67% of the patients receiving verum versus 46% in the placebo group (p = 0.037). There was a positive trend toward a larger decrease in the abscess sizes in the verum group compared to the placebo group (p = 0.07).</p><p><strong>Conclusion: </strong>The ointment studied is an effective and safe option for the treatment of bacterial skin diseases.</p>\",\"PeriodicalId\":10541,\"journal\":{\"name\":\"Complementary Medicine Research\",\"volume\":\"30 1\",\"pages\":\"56-62\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11078321/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Complementary Medicine Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1159/000528220\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/11/23 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"INTEGRATIVE & COMPLEMENTARY MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Complementary Medicine Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000528220","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/11/23 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}
引用次数: 0

摘要

背景:含松节油的物质被认为能有效治疗皮肤细菌感染,但可靠的临床数据却很少:目的:我们在一项随机、安慰剂对照、双盲研究中调查了含有落叶松松脂(来自落叶松)、桉树油(来自球叶桉树)和松脂油(来自松柏)的软膏对门诊疼痛性皮肤脓肿患者的疗效和安全性:116 名患有皮肤脓肿的门诊患者使用维鲁姆或安慰剂 10 天。患者的不适感总分、脓肿大小变化、治疗成功率和完全愈合作为结果参数:结果:54 名患者接受了维鲁姆治疗,56 名患者接受了安慰剂治疗。根据患者的不适感总分,维鲁姆组患者的不适感改善情况优于安慰剂组(7.3 分对 4.7 分;P = 0.024),调查人员的主观评估显示,维鲁姆治疗后的成功率更高(70% 对 48%;P = 0.021)。据记录,67%的患者接受了维鲁姆治疗,而安慰剂组为 46%(p = 0.037)。与安慰剂组相比,阿维菌素组的脓肿面积呈明显缩小趋势(p = 0.07):结论:所研究的药膏是治疗细菌性皮肤病的一种有效而安全的选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Turpentine Ointment in Bacterial Skin Infections: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial.

Background: Turpentine-containing substances are considered effective in treating cutaneous bacterial infections, but reliable clinical data are scant.

Objective: We investigated the efficacy and safety of an ointment containing larch turpentine (from Larix decidua), eucalyptus oil (from Eucalyptus globulus), and turpentine oil (from Pinus pinaster) in outpatients with painful skin abscesses in a randomized, placebo-controlled, double-blind study.

Intervention: 116 outpatients with skin abscesses used verum or placebo for 10 days. Sum score of the patient's discomforts, changes in abscess size, rate of therapeutic success, and complete healing served as outcome parameters.

Results: Fifty-four patients were treated with verum and 56 with placebo. According to the patient's discomfort sum score, patients in the verum group showed a better improvement compared to the placebo group (7.3 vs. 4.7; p = 0.024), and subjective assessment by the investigators revealed a higher treatment success rate after verum (70% vs. 48%; p = 0.021). Complete healing was documented in 67% of the patients receiving verum versus 46% in the placebo group (p = 0.037). There was a positive trend toward a larger decrease in the abscess sizes in the verum group compared to the placebo group (p = 0.07).

Conclusion: The ointment studied is an effective and safe option for the treatment of bacterial skin diseases.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Complementary Medicine Research
Complementary Medicine Research Medicine-Complementary and Alternative Medicine
CiteScore
2.90
自引率
5.60%
发文量
50
期刊介绍: Aims and Scope ''Complementary Medicine Research'' is an international journal that aims to bridge the gap between conventional medicine and complementary/alternative medicine (CAM) on a sound scientific basis, promoting their mutual integration. Accordingly, experts of both conventional medicine and CAM medicine cooperate on the journal‘s editorial board, which accepts papers only after a rigorous peer-review process in order to maintain a high standard of scientific quality. Spectrum of ''Complementary Medicine Research'': - Review and Original Articles, Case Reports and Essays regarding complementary practice and methods - Journal Club: Analysis and discussion of internationally published articles in complementary medicine - Editorials of leading experts in complementary medicine - Questions of complementary patient-centered care - Education in complementary medicine - Reports on important meetings and conferences - Society Bulletins of Schweizerische Medizinische Gesellschaft für Phytotherapie (SMGP) and Deutsche Gesellschaft für Naturheilkunde Bibliographic Details Complementary Medicine Research Journal Abbreviation: Complement Med Res ISSN: 2504-2092 (Print) e-ISSN: 2504-2106 (Online) DOI: 10.1159/issn.2504-2092 www.karger.com/CMR
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信