{"title":"预先确定的顺势疗法药物在接受标准治疗的无症状COVID-19患者中的比较效果——一项开放标签、随机、对照的探索性试验","authors":"Roja Varanasi, Sunita Tomar, Sanjay Gupta, Praveen Jaiswal, Ankit Srivastava, Vijendra Parmar, Shradha Chauhan, Arvind Kumar, Shivendra Kumar Mishra, Anil Khurana","doi":"10.1055/s-0042-1745754","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Asymptomatic COVID-19 subjects can transmit the infection for as many as 14 days and are regarded as a significant factor in the rapid spread of the COVID-19 pandemic. This exploratory study aimed to determine any additional benefits of selected homeopathic medicines compared with placebo in asymptomatic COVID-19 individuals receiving standard care.</p><p><strong>Methods: </strong>This open-label, randomized, placebo-controlled, exploratory trial was undertaken at a COVID Care Centre (CCC) in Madhya Pradesh, India. Patients (<i>n</i> = 200, 18-65 years, both sexes) having a positive RT-PCR and asymptomatic during admission were enrolled. They were randomly assigned to one of four groups (each <i>n</i> = 50): <i>Arsenicum album</i> 30C (<i>Ars. alb.</i>), <i>Camphora</i> 1M (<i>Camph</i>.), <i>Bryonia alba</i> 30C <i>(Bry. alb.)</i> and placebo (<i>Pl</i>.). All the patients were given standard care. The primary outcome was the number of patients becoming RT-PCR negative for SARS-CoV-2 at days 5, 10 and 15.</p><p><strong>Results: </strong>In total, 200 asymptomatic COVID-19 patients were enrolled. One hundred and seventy-seven patients became RT-PCR negative by day 15; 88%, 80%, 98% and 88% from <i>Ars. alb., Camph., Bry. alb.</i> and <i>Pl.</i> respectively. A Chi-square test of association for the total patients who became RT-PCR negative for SARS-Cov-2 in each group showed a marginal statistical significance (Chi-square: 8.1, <i>p</i> = 0.04). A two-proportion <i>Z</i>-test comparing each pre-identified homeopathic medicine with placebo showed marginal statistical significance (<i>p</i> = 0.05) for <i>Bry alb.</i> only. Median time in days to RT-PCR negative (Kaplan Meier analysis) was 10 days in each of the groups.</p><p><strong>Conclusion: </strong>There was some evidence that, compared with <i>Ars alb., Camph</i>. or <i>Pl.</i>, <i>Bry. alb.</i> was associated with an increased number of patients who became RT-PCR negative for COVID-19 by day 15. The possible effect exerted needs to be investigated in additional research.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":null,"pages":null},"PeriodicalIF":1.2000,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Comparative Effectiveness of Pre-Identified Homeopathic Medicines in Asymptomatic COVID-19 Individuals Receiving Standard Care-An Open-Label, Randomized, Controlled Exploratory Trial.\",\"authors\":\"Roja Varanasi, Sunita Tomar, Sanjay Gupta, Praveen Jaiswal, Ankit Srivastava, Vijendra Parmar, Shradha Chauhan, Arvind Kumar, Shivendra Kumar Mishra, Anil Khurana\",\"doi\":\"10.1055/s-0042-1745754\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Asymptomatic COVID-19 subjects can transmit the infection for as many as 14 days and are regarded as a significant factor in the rapid spread of the COVID-19 pandemic. This exploratory study aimed to determine any additional benefits of selected homeopathic medicines compared with placebo in asymptomatic COVID-19 individuals receiving standard care.</p><p><strong>Methods: </strong>This open-label, randomized, placebo-controlled, exploratory trial was undertaken at a COVID Care Centre (CCC) in Madhya Pradesh, India. Patients (<i>n</i> = 200, 18-65 years, both sexes) having a positive RT-PCR and asymptomatic during admission were enrolled. They were randomly assigned to one of four groups (each <i>n</i> = 50): <i>Arsenicum album</i> 30C (<i>Ars. alb.</i>), <i>Camphora</i> 1M (<i>Camph</i>.), <i>Bryonia alba</i> 30C <i>(Bry. alb.)</i> and placebo (<i>Pl</i>.). All the patients were given standard care. The primary outcome was the number of patients becoming RT-PCR negative for SARS-CoV-2 at days 5, 10 and 15.</p><p><strong>Results: </strong>In total, 200 asymptomatic COVID-19 patients were enrolled. One hundred and seventy-seven patients became RT-PCR negative by day 15; 88%, 80%, 98% and 88% from <i>Ars. alb., Camph., Bry. alb.</i> and <i>Pl.</i> respectively. A Chi-square test of association for the total patients who became RT-PCR negative for SARS-Cov-2 in each group showed a marginal statistical significance (Chi-square: 8.1, <i>p</i> = 0.04). A two-proportion <i>Z</i>-test comparing each pre-identified homeopathic medicine with placebo showed marginal statistical significance (<i>p</i> = 0.05) for <i>Bry alb.</i> only. Median time in days to RT-PCR negative (Kaplan Meier analysis) was 10 days in each of the groups.</p><p><strong>Conclusion: </strong>There was some evidence that, compared with <i>Ars alb., Camph</i>. or <i>Pl.</i>, <i>Bry. alb.</i> was associated with an increased number of patients who became RT-PCR negative for COVID-19 by day 15. The possible effect exerted needs to be investigated in additional research.</p>\",\"PeriodicalId\":13227,\"journal\":{\"name\":\"Homeopathy\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2022-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Homeopathy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1055/s-0042-1745754\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"INTEGRATIVE & COMPLEMENTARY MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Homeopathy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1055/s-0042-1745754","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}
Comparative Effectiveness of Pre-Identified Homeopathic Medicines in Asymptomatic COVID-19 Individuals Receiving Standard Care-An Open-Label, Randomized, Controlled Exploratory Trial.
Background: Asymptomatic COVID-19 subjects can transmit the infection for as many as 14 days and are regarded as a significant factor in the rapid spread of the COVID-19 pandemic. This exploratory study aimed to determine any additional benefits of selected homeopathic medicines compared with placebo in asymptomatic COVID-19 individuals receiving standard care.
Methods: This open-label, randomized, placebo-controlled, exploratory trial was undertaken at a COVID Care Centre (CCC) in Madhya Pradesh, India. Patients (n = 200, 18-65 years, both sexes) having a positive RT-PCR and asymptomatic during admission were enrolled. They were randomly assigned to one of four groups (each n = 50): Arsenicum album 30C (Ars. alb.), Camphora 1M (Camph.), Bryonia alba 30C (Bry. alb.) and placebo (Pl.). All the patients were given standard care. The primary outcome was the number of patients becoming RT-PCR negative for SARS-CoV-2 at days 5, 10 and 15.
Results: In total, 200 asymptomatic COVID-19 patients were enrolled. One hundred and seventy-seven patients became RT-PCR negative by day 15; 88%, 80%, 98% and 88% from Ars. alb., Camph., Bry. alb. and Pl. respectively. A Chi-square test of association for the total patients who became RT-PCR negative for SARS-Cov-2 in each group showed a marginal statistical significance (Chi-square: 8.1, p = 0.04). A two-proportion Z-test comparing each pre-identified homeopathic medicine with placebo showed marginal statistical significance (p = 0.05) for Bry alb. only. Median time in days to RT-PCR negative (Kaplan Meier analysis) was 10 days in each of the groups.
Conclusion: There was some evidence that, compared with Ars alb., Camph. or Pl., Bry. alb. was associated with an increased number of patients who became RT-PCR negative for COVID-19 by day 15. The possible effect exerted needs to be investigated in additional research.
期刊介绍：
Homeopathy is an international peer-reviewed journal aimed at improving the fundamental understanding and clinical practice of homeopathy by publishing relevant high-quality original research articles, reviews, and case reports. It also promotes commentary and debate on matters of topical interest in homeopathy.
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