Joshua Muhumuza, Selamo Fabrice Molen, William Mauricio, Jorge Soria La O, Jethro Atumanyire, Nyenke Bassara Godefroy, Musa Abbas Waziri, Stephen Mbae Kithinji, Kiyaka Magugu Sonye, Mugisho Munyerenkana Leocadie, Franck Katembo Sikakulya, ByaMungu Pahari Kagenderezo, Musafiri Simba Lionel, Mumin Farah, Herman Lule
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引用次数: 0
摘要
背景:术后回肠梗阻时间过长会增加其他并发症的风险、住院时间和医疗相关费用。在许多择期手术中,咀嚼口香糖已被证明可缩短回肠持续时间,但在接受急诊手术的患者(尤其是腹膜炎患者)中,有关口香糖对回肠持续时间影响的随机对照试验(RCT)却很少。本研究旨在确定口香糖对胃十二指肠穿孔开腹手术后回肠持续时间的影响:方法:这是一项在 3 家医院进行的随机对照试验。52 名患者将被随机分为两组。A 组除常规护理外还将接受口香糖治疗,而 B 组仅接受常规护理。两组患者术后回肠梗阻的持续时间(这是主要结果)将通过 SPSS 22 版的独立样本 t 检验进行比较。住院时间、院内发病率和死亡率将作为次要结果。该试验已获得坎帕拉国际大学研究与伦理委员会(编号:KIU-2021-60)和乌干达国家科学技术委员会(编号:HS1665ES)的批准。此外,还在研究登记处进行了回顾性登记(UIN:researchregistry8565):在许多择期手术中,咀嚼口香糖已被证明可以缩短回肠梗阻的时间。
Effect of Chewing Gum on Duration of Postoperative Ileus Following Laparotomy for Gastroduodenal Perforations: Protocol for a Randomized Controlled Trial.
Background: Prolonged post-operative ileus is associated with increased risk of other complications, length of hospital stays and health care related costs. Chewing gum has been shown to reduce duration of ileus in many elective surgeries, but there is a paucity of randomised controlled trials (RCTs) on its effect on duration of ileus among patients undergoing emergency surgery, specifically patients with peritonitis. The aim of this study is to determine the effect of chewing gum on duration of postoperative ileus following laparotomy for gastroduodenal perforations.
Methods: This will be a randomised controlled trial done in 3 hospitals. Fifty-two patients will be randomised to 2 groups. Group A will receive chewing gum in addition to routine care, whereas group B will receive routine care only. The duration of post-operative ileus in the two groups which is the primary outcome, will be compared using the independent samples t-test in SPSS version 22. The length of hospital stay, in-hospital morbidity and mortality will be the secondary outcomes. This trial has been approved by Kampala International University research and Ethics committee (Ref No. KIU-2021-60) and Uganda national council of science and technology (Ref No. HS1665ES). Retrospective registration with the research registry has also been done (UIN: researchregistry8565).
Highlights: Prolonged post-operative ileus significantly contributes to adverse surgical outcomesChewing gum has been shown to reduce duration of ileus in many elective surgeriesThere is paucity of RCTs on role of chewing gum following surgery for peritonitis.
期刊介绍:
IJS Protocols is the first peer-reviewed, international, open access journal seeking to publish research protocols across across the full breadth of the surgical field. We are aim to provide rapid submission to decision times whilst maintaining a high quality peer-review process.