肠道微生物的合成群落在动物健康和营养的基础研究和转化方法。

IF 8.7 1区 农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE
Susan A V Jennings, Thomas Clavel
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引用次数: 0

摘要

微生物与动物之间存在着一种共生关系,这种关系极大地影响着动物的营养吸收和健康。这种关系可以通过选择被称为合成群落(SynComs)的微生物来研究。syncom被用于许多不同的动物宿主,包括农业动物,以研究微生物与营养物质的相互作用以及这些相互作用如何影响动物健康。目前,SynComs最常见的宿主是小鼠和人类,从基础机制研究到转化疾病模型和活体生物治疗产品(lbp)作为治疗方法。我们讨论了与人类和动物健康和营养有关的基础研究模型和发现中使用的SynComs。讨论了SynCom的翻译用例,然后是lbp,特别是在农业背景下。SynComs仍然面临着挑战,例如可重复性和污染风险的标准化。然而,SynCom的未来是充满希望的,特别是在基因组引导的SynCom设计和定制基于SynCom的治疗领域。预计《动物生物科学年度评论》第12卷的最终在线出版日期是2024年2月。修订后的估计数请参阅http://www.annualreviews.org/page/journal/pubdates。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Synthetic Communities of Gut Microbes for Basic Research and Translational Approaches in Animal Health and Nutrition.

Microbes and animals have a symbiotic relationship that greatly influences nutrient uptake and animal health. This relationship can be studied using selections of microbes termed synthetic communities, or SynComs. SynComs are used in many different animal hosts, including agricultural animals, to investigate microbial interactions with nutrients and how these affect animal health. The most common host focuses for SynComs are currently mouse and human, from basic mechanistic research through to translational disease models and live biotherapeutic products (LBPs) as treatments. We discuss SynComs used in basic research models and findings that relate to human and animal health and nutrition. Translational use cases of SynComs are discussed, followed by LBPs, especially within the context of agriculture. SynComs still face challenges, such as standardization for reproducibility and contamination risks. However, the future of SynComs is hopeful, especially in the areas of genome-guided SynCom design and custom SynCom-based treatments.

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来源期刊
Annual Review of Animal Biosciences
Annual Review of Animal Biosciences BIOTECHNOLOGY & APPLIED MICROBIOLOGY-ZOOLOGY
CiteScore
21.30
自引率
0.80%
发文量
31
期刊介绍: The Annual Review of Animal Biosciences is primarily dedicated to the fields of biotechnology, genetics, genomics, and breeding, with a special focus on veterinary medicine. This includes veterinary pathobiology, infectious diseases and vaccine development, and conservation and zoo biology. The publication aims to address the needs of scientists studying both wild and domesticated animal species, veterinarians, conservation biologists, and geneticists.
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