培养肉细胞生物学研究进展与挑战。

IF 8.7 1区 农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE
Beatriz Martins, Arthur Bister, Richard G J Dohmen, Maria Ana Gouveia, Rui Hueber, Lea Melzener, Tobias Messmer, Joanna Papadopoulos, Joana Pimenta, Dhruv Raina, Lieke Schaeken, Sara Shirley, Benjamin P Bouchet, Joshua E Flack
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引用次数: 0

摘要

人造肉是一种新兴的生物技术,旨在从环境和动物福利的角度出发,从动物细胞培养中生产肉,而不是从饲养和屠宰牲畜中生产肉。细胞生物学的详细理解和准确操作对培养肉生物工艺的设计至关重要。近年来,人们对这一领域产生了浓厚的兴趣,在科学和商业上取得了许多突破。尽管如此,这些技术仍处于起步阶段,并且跨越整个生物过程的无数挑战仍然存在。从细胞生物学的角度来看,这些包括确定合适的起始细胞类型,调节增殖和分化条件,以及优化细胞-生物材料相互作用以创造营养丰富,诱人的食物。在这里,我们讨论了培养肉的关键进展和突出的挑战,特别关注细胞生物学,并认为以具有成本效益,可扩展的方式解决剩余的瓶颈将需要协调一致的科学努力。成功还需要解决非科学挑战,包括监管批准、消费者接受度和市场可行性。然而,如果能克服这些问题,人造肉技术将彻底改变我们的饮食方式。预计《动物生物科学年度评论》第12卷的最终在线出版日期是2024年2月。修订后的估计数请参阅http://www.annualreviews.org/page/journal/pubdates。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Advances and Challenges in Cell Biology for Cultured Meat.

Cultured meat is an emerging biotechnology that aims to produce meat from animal cell culture, rather than from the raising and slaughtering of livestock, on environmental and animal welfare grounds. The detailed understanding and accurate manipulation of cell biology are critical to the design of cultured meat bioprocesses. Recent years have seen significant interest in this field, with numerous scientific and commercial breakthroughs. Nevertheless, these technologies remain at a nascent stage, and myriad challenges remain, spanning the entire bioprocess. From a cell biological perspective, these include the identification of suitable starting cell types, tuning of proliferation and differentiation conditions, and optimization of cell-biomaterial interactions to create nutritious, enticing foods. Here, we discuss the key advances and outstanding challenges in cultured meat, with a particular focus on cell biology, and argue that solving the remaining bottlenecks in a cost-effective, scalable fashion will require coordinated, concerted scientific efforts. Success will also require solutions to nonscientific challenges, including regulatory approval, consumer acceptance, and market feasibility. However, if these can be overcome, cultured meat technologies can revolutionize our approach to food.

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来源期刊
Annual Review of Animal Biosciences
Annual Review of Animal Biosciences BIOTECHNOLOGY & APPLIED MICROBIOLOGY-ZOOLOGY
CiteScore
21.30
自引率
0.80%
发文量
31
期刊介绍: The Annual Review of Animal Biosciences is primarily dedicated to the fields of biotechnology, genetics, genomics, and breeding, with a special focus on veterinary medicine. This includes veterinary pathobiology, infectious diseases and vaccine development, and conservation and zoo biology. The publication aims to address the needs of scientists studying both wild and domesticated animal species, veterinarians, conservation biologists, and geneticists.
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