腹部肥胖可能在多囊卵巢综合征患者炎症加重中起重要作用。

IF 1.8 Q3 OBSTETRICS & GYNECOLOGY
Fatemeh Shirvanizadeh, Akram Eidi, Maryam Hafezi, Poopak Eftekhari-Yazdi
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引用次数: 0

摘要

目的:多囊卵巢综合征(PCOS)是一种内分泌紊乱,似乎在许多层面上具有促炎作用,腹部肥胖(AO)是PCOS患者中普遍存在的促炎表型,它似乎有助于PCOS患者炎症的发生或恶化。在本研究中,我们研究了AO表型在PCOS患者其他肥胖指标(颈部和手臂)的发生以及卵泡液(FF)炎症增强中的作用。方法:40例年龄在35岁以下的PCOS患者分为4组:PCOS合并AO、PCOS不合并AO、非PCOS合并AO和非PCOS不合并AO。从每位患者身上采集FF样本。使用酶联免疫吸附法定量评估参与者的临床和人体特征,以及FF样品中的肿瘤坏死因子-α (TNF-α)浓度。对检索到的卵母细胞卵母细胞复合体(COC)的数量和质量进行评分。结果:与其他组相比,PCOS+AO+组颈围明显增加(p0.05)。结论:考虑到炎症在PCOS发展中的重要作用,管理PCOS患者的AO可能有助于减少炎症,并可能有助于设计定制的治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Abdominal Obesity May Play a Significant Role in inflammation Exacerbation in Polycystic Ovary Syndrome Patients.

Objective: Polycystic ovary syndrome (PCOS) is an endocrine disorder that seems to be pro-inflammatory at many levels, abdominal obesity (AO) is a prevalent pro-inflammatory phenotype in PCOS patients, and it seems to contribute to the initiation or worsening of inflammation in PCOS patients. In this study, we investigated the role of the AO phenotype in the occurrence of other obesity indicators (neck and arm) and augmentation of inflammation in the follicular fluid (FF) of PCOS patients.

Methods: 40 patients under the age of 35 were divided into four groups: PCOS with AO, PCOS without AO, non-PCOS with AO, and non-PCOS without AO. The FF samples were collected from each patient. Clinical and anthropometric characteristics of the participants, as well as tumor necrosis factor-α (TNF-α) concentration in the FF samples, were quantitatively assessed using enzyme-linked immunosorbent assays. The number of retrieved cumulus-oocyte complexes (COC) and their quality were scored.

Results: The PCOS+AO+ group had significantly increased neck circumference, compared to the other groups (p<0.001). The concentration of TNF-α was significantly higher in the PCOS+AO+ group than in the other groups (p<0.001). There were no significant differences in the number of retrieved COC per patient and the quality of oocytes between the groups (p>0.05).

Conclusions: Given the significant role of inflammation in the development of PCOS, managing AO in PCOS patients may aid in reducing inflammation and could potentially help in the design of customized treatment approaches.

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来源期刊
CiteScore
3.30
自引率
6.70%
发文量
56
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