神经元和突触水平的记忆分配。

IF 2.9 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

BMB Reports Pub Date : 2024-04-01

HyoJin Park, Bong-Kiun Kaang

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引用次数: 0

摘要

记忆分配决定了记忆在特定神经元或突触中的存储位置，一直被证明是通过特定机制发生的。神经元分配研究主要集中在激活的神经元群上，并表明通过cAMP反应元件结合蛋白(CREB)增加的兴奋性诱导了对记忆编码神经元的偏好。突触分配表明，即使在单个神经元内，突触标记也可以通过不同的突触强化机制来调节记忆。在这篇综述中，我们总结了记忆分配在神经元和突触水平上的基本概念，并讨论了它们之间潜在的相互关系。

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Memory allocation at the neuronal and synaptic levels.

Memory allocation, which determines where memories are stored in specific neurons or synapses, has consistently been demonstrated to occur via specific mechanisms. Neuronal allocation studies have focused on the activated population of neurons and have shown that increased excitability via cAMP response element-binding protein (CREB) induces a bias toward memoryencoding neurons. Synaptic allocation suggests that synaptic tagging enables memory to be mediated through different synaptic strengthening mechanisms, even within a single neuron. In this review, we summarize the fundamental concepts of memory allocation at the neuronal and synaptic levels and discuss their potential interrelationships. [BMB Reports 2024; 57(4): 176-181].

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来源期刊

BMB Reports 生物-生化与分子生物学

CiteScore

5.10

自引率

7.90%

发文量

141

审稿时长

1 months

期刊介绍： The BMB Reports (BMB Rep, established in 1968) is published at the end of every month by Korean Society for Biochemistry and Molecular Biology. Copyright is reserved by the Society. The journal publishes short articles and mini reviews. We expect that the BMB Reports will deliver the new scientific findings and knowledge to our readers in fast and timely manner.