Conner Blackwell, Shian McLeish, David Iglesias, Shannon D Armbruster
{"title":"伪装成妊娠滋养细胞肿瘤的畸形精原细胞瘤","authors":"Conner Blackwell, Shian McLeish, David Iglesias, Shannon D Armbruster","doi":"10.1155/2023/1901858","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Persistent elevation in beta-human chorionic gonadotropin (<i>β</i>-hCG) following a pregnancy is concerning for gestational trophoblastic neoplasia (GTN). However, the differential diagnosis should remain broad during the evaluation process.</p><p><strong>Case: </strong>A 34-year-old G3P3 presented with elevated <i>β</i>-hCG four months after cesarean delivery with bilateral tubal ligation. The patient was treated with methotrexate for a presumed new ectopic pregnancy. Due to persistent <i>β</i>-hCG elevation, she received actinomycin-D for GTN treatment. After completing chemotherapy, her <i>β</i>-hCG increased. The patient underwent a laparoscopic hysterectomy with unplanned left oophorectomy due to its nodular appearance at the time of surgery. Pathology confirmed a dysgerminoma of the ovary and benign uterus.</p><p><strong>Conclusion: </strong>Although dysgerminomas are uncommon, they should be considered when <i>β</i>-hCG levels remain elevated despite therapies for more common pathologies.</p>","PeriodicalId":9610,"journal":{"name":"Case Reports in Obstetrics and Gynecology","volume":"2023 ","pages":"1901858"},"PeriodicalIF":0.6000,"publicationDate":"2023-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931483/pdf/","citationCount":"0","resultStr":"{\"title\":\"Dysgerminoma Masquerading as Gestational Trophoblastic Neoplasia.\",\"authors\":\"Conner Blackwell, Shian McLeish, David Iglesias, Shannon D Armbruster\",\"doi\":\"10.1155/2023/1901858\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Persistent elevation in beta-human chorionic gonadotropin (<i>β</i>-hCG) following a pregnancy is concerning for gestational trophoblastic neoplasia (GTN). However, the differential diagnosis should remain broad during the evaluation process.</p><p><strong>Case: </strong>A 34-year-old G3P3 presented with elevated <i>β</i>-hCG four months after cesarean delivery with bilateral tubal ligation. The patient was treated with methotrexate for a presumed new ectopic pregnancy. Due to persistent <i>β</i>-hCG elevation, she received actinomycin-D for GTN treatment. After completing chemotherapy, her <i>β</i>-hCG increased. The patient underwent a laparoscopic hysterectomy with unplanned left oophorectomy due to its nodular appearance at the time of surgery. Pathology confirmed a dysgerminoma of the ovary and benign uterus.</p><p><strong>Conclusion: </strong>Although dysgerminomas are uncommon, they should be considered when <i>β</i>-hCG levels remain elevated despite therapies for more common pathologies.</p>\",\"PeriodicalId\":9610,\"journal\":{\"name\":\"Case Reports in Obstetrics and Gynecology\",\"volume\":\"2023 \",\"pages\":\"1901858\"},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2023-02-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931483/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Case Reports in Obstetrics and Gynecology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1155/2023/1901858\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Case Reports in Obstetrics and Gynecology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2023/1901858","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
Dysgerminoma Masquerading as Gestational Trophoblastic Neoplasia.
Background: Persistent elevation in beta-human chorionic gonadotropin (β-hCG) following a pregnancy is concerning for gestational trophoblastic neoplasia (GTN). However, the differential diagnosis should remain broad during the evaluation process.
Case: A 34-year-old G3P3 presented with elevated β-hCG four months after cesarean delivery with bilateral tubal ligation. The patient was treated with methotrexate for a presumed new ectopic pregnancy. Due to persistent β-hCG elevation, she received actinomycin-D for GTN treatment. After completing chemotherapy, her β-hCG increased. The patient underwent a laparoscopic hysterectomy with unplanned left oophorectomy due to its nodular appearance at the time of surgery. Pathology confirmed a dysgerminoma of the ovary and benign uterus.
Conclusion: Although dysgerminomas are uncommon, they should be considered when β-hCG levels remain elevated despite therapies for more common pathologies.
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