流感病毒mrna剪接和核输出过程中病毒与宿主的相互作用

IF 5.7 2区 医学 Q1 VIROLOGY
Matthew Esparza, Prasanna Bhat, Beatriz MA Fontoura
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引用次数: 7

摘要

当流感a- a病毒(IAV)在宿主细胞核中复制时,病毒基因表达的核内途径被篡夺。IAV的8个基因组病毒核糖核蛋白(vRNPs)片段被转录,其中两个片段产生病毒mrna (M和NS),它们经过选择性剪接,然后从细胞核输出。本文就病毒RNA剪接与核输出进行综述。最近关于M和NS剪接的机制进展表明,它们受到rna结合蛋白的不同调控以及不同的核内定位。在回顾了IAV剪接之后,我们将讨论病毒mRNA的核输出,这是通过与宿主mRNA输出机制的特定成分相互作用而发生的,宿主mRNA输出机制通过核孔复合物将病毒mRNA转运到细胞质中进行翻译。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Viral–host interactions during splicing and nuclear export of influenza virus mRNAs

Viral–host interactions during splicing and nuclear export of influenza virus mRNAs

Viral–host interactions during splicing and nuclear export of influenza virus mRNAs

Viral–host interactions during splicing and nuclear export of influenza virus mRNAs

As influenza-A viruses (IAV) replicate in the host cell nucleus, intranuclear pathways are usurped for viral gene expression. The eight genomic viral ribonucleoproteins (vRNPs) segments of IAV are transcribed and two generate viral mRNAs (M and NS) that undergo alternative splicing followed by export from the nucleus. The focus of this review is on viral RNA splicing and nuclear export. Recent mechanistic advances on M and NS splicing show differential regulation by RNA-binding proteins as well as distinct intranuclear localization. After a review of IAV splicing, we will discuss the nuclear export of viral mRNAs, which occur by interacting with specific constituents of the host mRNA export machinery that translocate viral mRNAs through the nuclear pore complex for translation in the cytoplasm.

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来源期刊
CiteScore
11.80
自引率
5.10%
发文量
76
审稿时长
83 days
期刊介绍: Current Opinion in Virology (COVIRO) is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up to date with the expanding volume of information published in the field of virology. It publishes 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Emerging viruses: interspecies transmission; Viral immunology; Viral pathogenesis; Preventive and therapeutic vaccines; Antiviral strategies; Virus structure and expression; Animal models for viral diseases; Engineering for viral resistance; Viruses and cancer; Virus vector interactions. There is also a section that changes every year to reflect hot topics in the field.
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