非糖尿病韩国成人高尿酸血症与胰岛素抵抗和β细胞功能关联的性别差异:2019年韩国国民健康与营养调查

IF 1.5 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Endocrine Research Pub Date : 2023-02-01 DOI:10.1080/07435800.2022.2142239

Jeong Min Seong, Mi Young Gi, Ju Ae Cha, Hyun Ho Sung, So Young Park, Cho Hee Park, Hyun Yoon

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引用次数: 0

摘要

目的:本研究旨在评估韩国非糖尿病成年人中尿酸(UA)与胰岛素抵抗(HOMA-IR)和β细胞功能(HOMA-B)的稳态模型评估的相关性。材料和方法:该研究使用2019年韩国国民健康和营养检查调查的数据进行，包括20岁及以上的非糖尿病韩国男性、绝经前女性和绝经后女性。结果:首先，在对相关变量(不包括肥胖)进行调整后，高尿酸血症的患病率(男性UA≥7.0 mg/dL或女性UA≥6.0 mg/dL)与男性、绝经前女性和绝经后女性的HOMA-IR和HOMA-B的四分位数呈正相关。其次，当进一步调整肥胖因素时，高尿酸血症与男性和绝经后妇女的HOMA-IR和HOMA-B四分位数呈正相关，但与绝经前妇女无关。第三，在校正了相关变量(包括肥胖)后，UA水平与男性和绝经后女性的HOMA-IR和HOMA-B四分位数呈正相关，而绝经前女性则没有。结论:高尿酸血症与韩国非糖尿病男性和绝经后女性的胰岛素抵抗和β细胞功能呈正相关，但与绝经前女性无关。

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Gender Difference in the Association of Hyperuricemia with Insulin Resistance and beta-cell Function in Nondiabetic Korean Adults: The 2019 Korea National Health and Nutrition Examination Survey.

Aims: This study was conducted to assess the association of uric acid (UA) with the homeostasis model assessment of insulin resistance (HOMA-IR) and beta-cell function (HOMA-B) by gender in nondiabetic Korean adults.

Materials and methods: The study was carried out using data from the 2019 Korean National Health and Nutrition Examination Survey and included nondiabetic Korean men, premenopausal women, and postmenopausal women aged 20 years or older.

Results: First, after adjusted for the related variables (excluding obesity), the prevalence of hyperuricemia (UA ≥ 7.0 mg/dL in men or UA ≥ 6.0 mg/dL in women) was positively associated with the quartiles of HOMA-IR and HOMA-B in men, premenopausal women, and postmenopausal women. Second, when further adjusted for obesity, hyperuricemia was positively associated with the quartiles of HOMA-IR and HOMA-B in men and postmenopausal women but not in premenopausal women. Third, after adjusted for the related variables (including obesity), UA level was positively associated with the quartiles of HOMA-IR and HOMA-B in men and postmenopausal women but not in premenopausal women.

Conclusions: hyperuricemia is positively associated with insulin resistance and beta-cell function in nondiabetic Korean men and postmenopausal women but not in premenopausal women.

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来源期刊

Endocrine Research 医学-内分泌学与代谢

CiteScore

4.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： This journal publishes original articles relating to endocrinology in the broadest context. Subjects of interest include: receptors and mechanism of action of hormones, methodological advances in the detection and measurement of hormones; structure and chemical properties of hormones. Invitations to submit Brief Reviews are issued to specific authors by the Editors.