Chunrong Ju, Yalan Yang, Qiaoyan Lian, Lulin Wang, Xiaohua Wang, Bing Wei, Danxia Huang, Xin Xu, Jianxing He
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引用次数: 2
摘要
背景:与工作有关的肺病(WRLD)患者因严重的肺组织损伤和纤维化而死亡的风险增加。本研究旨在评估肺移植(LTx)治疗WRLD的临床结果，并比较WRLD和特发性肺纤维化(IPF)的肺移植结果。方法:本单中心回顾性队列研究回顾了2015年1月至2021年12月在我院因wld或IPF接受LTx治疗的患者的临床资料。使用Kaplan-Meier法估计LTx后的累积生存率。结果:最终分析wld 33例，IPF 91例。33例wld患者中，矽肺19例(57.6%)，煤工尘肺8例(24.2%)，石棉肺3例(9.09%)，其他wld 3例(9.09%)。气胸作为LTx的适应症在WRLD组中比在IPF组中更为常见(51.5% vs. 2.2%)。结论:LTx在WRLD和IPF患者中具有相似的生存结局和肺功能。气胸是肺移植的主要指征。
Clinical outcomes and survival following lung transplantation for work-related lung disease: a single-center retrospective cohort study.
Background: Patients with work-related lung disease (WRLD) are at increased risk of death caused by severe lung tissue damage and fibrosis. This study aimed to assess the clinical outcomes of lung transplantation (LTx) for WRLD and compare the results of LTx between WRLD and idiopathic pulmonary fibrosis (IPF).
Methods: This single-center retrospective cohort study reviewed the clinical data of patients who underwent LTx for WRLD or IPF at our hospital between January 2015 and December 2021. Cumulative survival rates after LTx were estimated using the Kaplan-Meier method.
Results: The final analysis included 33 cases of WRLD and 91 cases of IPF. The 33 WRLD patients consisted of 19 (57.6%) cases of silicosis, 8 (24.2%) cases of coal workers' pneumoconiosis, 3 (9.09%) cases of asbestosis, and 3 (9.09%) cases of other WRLD. Pneumothorax as an indication for LTx was significantly more common in the WRLD group than in the IPF group (51.5% vs. 2.2%, P < 0.001). There was no significant difference in the 5-year cumulative survival rate between the WRLD patients and the IPF patients (66.6% vs. 56.7%, P = 0.67). There was no significant difference in the best performance of exercise capacity and lung function between the two groups at 1 year post-transplant.
Conclusions: LTx had similar survival outcomes and lung function for WRLD and IPF patients. Pneumothorax was the primary indication for lung transplantation in WRLD.
期刊介绍：
Aimed at clinicians and researchers, the Journal of Occupational Medicine and Toxicology is a multi-disciplinary, open access journal which publishes original research on the clinical and scientific aspects of occupational and environmental health.
With high-quality peer review and quick decision times, we welcome submissions on the diagnosis, prevention, management, and scientific analysis of occupational diseases, injuries, and disability. The journal also covers the promotion of health of workers, their families, and communities, and ranges from rehabilitation to tropical medicine and public health aspects.
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