大麻二酚用于犬猫疾病管理的科学验证。

IF 8.7 1区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Annual Review of Animal Biosciences Pub Date : 2023-02-15 DOI:10.1146/annurev-animal-081122-070236

Isabella Corsato Alvarenga, Kiran S Panickar, Hannah Hess, Stephanie McGrath

{"title":"大麻二酚用于犬猫疾病管理的科学验证。","authors":"Isabella Corsato Alvarenga, Kiran S Panickar, Hannah Hess, Stephanie McGrath","doi":"10.1146/annurev-animal-081122-070236","DOIUrl":null,"url":null,"abstract":"Cannabidiol (CBD) is a non-psychotropic phytocannabinoid of the plant Cannabis sativa L. CBD is increasingly being explored as an alternative to conventional therapies to treat health disorders in dogs and cats. Mechanisms of action of CBD have been investigated mostly in rodents and in vitro and include modulation of CB1, CB2, 5-HT, GPR, and opioid receptors. In companion animals, CBD appears to have good bioavailability and safety profile with few side effects at physiological doses. Some dog studies have found CBD to improve clinical signs associated with osteoarthritis, pruritus, and epilepsy. However, further studies are needed to conclude a therapeutic action of CBD for each of these conditions, as well as for decreasing anxiety and aggression in dogs and cats. Herein, we summarize the available scientific evidence associated with the mechanisms of action of CBD, including pharmacokinetics, safety, regulation, and efficacy in ameliorating various health conditions in dogs and cats.","PeriodicalId":48953,"journal":{"name":"Annual Review of Animal Biosciences","volume":"11 ","pages":"227-246"},"PeriodicalIF":8.7000,"publicationDate":"2023-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"7","resultStr":"{\"title\":\"Scientific Validation of Cannabidiol for Management of Dog and Cat Diseases.\",\"authors\":\"Isabella Corsato Alvarenga, Kiran S Panickar, Hannah Hess, Stephanie McGrath\",\"doi\":\"10.1146/annurev-animal-081122-070236\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Cannabidiol (CBD) is a non-psychotropic phytocannabinoid of the plant Cannabis sativa L. CBD is increasingly being explored as an alternative to conventional therapies to treat health disorders in dogs and cats. Mechanisms of action of CBD have been investigated mostly in rodents and in vitro and include modulation of CB1, CB2, 5-HT, GPR, and opioid receptors. In companion animals, CBD appears to have good bioavailability and safety profile with few side effects at physiological doses. Some dog studies have found CBD to improve clinical signs associated with osteoarthritis, pruritus, and epilepsy. However, further studies are needed to conclude a therapeutic action of CBD for each of these conditions, as well as for decreasing anxiety and aggression in dogs and cats. Herein, we summarize the available scientific evidence associated with the mechanisms of action of CBD, including pharmacokinetics, safety, regulation, and efficacy in ameliorating various health conditions in dogs and cats.\",\"PeriodicalId\":48953,\"journal\":{\"name\":\"Annual Review of Animal Biosciences\",\"volume\":\"11 \",\"pages\":\"227-246\"},\"PeriodicalIF\":8.7000,\"publicationDate\":\"2023-02-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annual Review of Animal Biosciences\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.1146/annurev-animal-081122-070236\",\"RegionNum\":1,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"AGRICULTURE, DAIRY & ANIMAL SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annual Review of Animal Biosciences","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1146/annurev-animal-081122-070236","RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"AGRICULTURE, DAIRY & ANIMAL SCIENCE","Score":null,"Total":0}

引用次数: 7

摘要

大麻二酚(CBD)是植物大麻中的一种非精神药物植物大麻素。CBD越来越多地被探索作为治疗狗和猫健康疾病的传统疗法的替代疗法。CBD的作用机制主要在啮齿动物和体外研究，包括调节CB1, CB2, 5-HT, GPR和阿片受体。在伴侣动物中，CBD似乎具有良好的生物利用度和安全性，在生理剂量下几乎没有副作用。一些对狗的研究发现，CBD可以改善与骨关节炎、瘙痒症和癫痫有关的临床症状。然而，需要进一步的研究来确定CBD对这些疾病的治疗作用，以及减少狗和猫的焦虑和攻击性。在此，我们总结了与CBD作用机制相关的现有科学证据，包括药代动力学、安全性、监管和改善狗和猫各种健康状况的有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Scientific Validation of Cannabidiol for Management of Dog and Cat Diseases.

Cannabidiol (CBD) is a non-psychotropic phytocannabinoid of the plant Cannabis sativa L. CBD is increasingly being explored as an alternative to conventional therapies to treat health disorders in dogs and cats. Mechanisms of action of CBD have been investigated mostly in rodents and in vitro and include modulation of CB1, CB2, 5-HT, GPR, and opioid receptors. In companion animals, CBD appears to have good bioavailability and safety profile with few side effects at physiological doses. Some dog studies have found CBD to improve clinical signs associated with osteoarthritis, pruritus, and epilepsy. However, further studies are needed to conclude a therapeutic action of CBD for each of these conditions, as well as for decreasing anxiety and aggression in dogs and cats. Herein, we summarize the available scientific evidence associated with the mechanisms of action of CBD, including pharmacokinetics, safety, regulation, and efficacy in ameliorating various health conditions in dogs and cats.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Annual Review of Animal Biosciences BIOTECHNOLOGY & APPLIED MICROBIOLOGY-ZOOLOGY

CiteScore

21.30

自引率

0.80%

发文量

期刊介绍： The Annual Review of Animal Biosciences is primarily dedicated to the fields of biotechnology, genetics, genomics, and breeding, with a special focus on veterinary medicine. This includes veterinary pathobiology, infectious diseases and vaccine development, and conservation and zoo biology. The publication aims to address the needs of scientists studying both wild and domesticated animal species, veterinarians, conservation biologists, and geneticists.