婴儿与幼儿依恋类型外周血DNA甲基化和估计单核细胞比例差异的关系。

IF 3.3 2区 心理学 Q1 PSYCHOLOGY, DEVELOPMENTAL
Sarah M Merrill, Nicole Gladish, Maggie P Fu, Sarah R Moore, Chaini Konwar, Gerald F Giesbrecht, Julia L MacIssac, Michael S Kobor, Nicole L Letourneau
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引用次数: 10

摘要

依恋是一种激励系统,促进对照顾者的安全感,从而产生持久的人际行为的内部工作模式。依恋类型是在早期社会环境中形成的,并通过潜在的生物特征(如DNA甲基化(DNAm)等表观遗传修饰)预测未来的健康和发展结果。因此,我们假设婴儿DNAm与幼儿依恋类型有关。一项3月龄婴儿血液dna全表观基因组关联研究(EWAS)在22月龄时通过奇怪情境程序在多个dna胞嘧啶-磷酸-鸟嘌呤(CpG)位点回归到儿童的依恋类型。这26个鉴定出的CpGs与促炎免疫表型和认知发育相关。在事后分析中,只有母亲的认知成长促进,鼓励智力探索,有贡献。对于混乱的儿童,dnam衍生的细胞类型比例估计更高的单核细胞-免疫反应中的细胞假设随着早期逆境的增加而增加。总的来说,这些发现表明,不利和有利的社会环境的潜在生物嵌入早在3个月大。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Associations of peripheral blood DNA methylation and estimated monocyte proportion differences during infancy with toddler attachment style.

Attachment is a motivational system promoting felt security to a caregiver resulting in a persistent internal working model of interpersonal behavior. Attachment styles are developed in early social environments and predict future health and development outcomes with potential biological signatures, such as epigenetic modifications like DNA methylation (DNAm). Thus, we hypothesized infant DNAm would associate with toddler attachment styles. An epigenome-wide association study (EWAS) of blood DNAm from 3-month-old infants was regressed onto children's attachment style from the Strange Situation Procedure at 22-months at multiple DNAm Cytosine-phosphate-Guanine (CpG) sites. The 26 identified CpGs associated with proinflammatory immune phenotypes and cognitive development. In post-hoc analyses, only maternal cognitive-growth fostering, encouraging intellectual exploration, contributed. For disorganized children, DNAm-derived cell-type proportions estimated higher monocytes -cells in immune responses hypothesized to increase with early adversity. Collectively, these findings suggested the potential biological embedding of both adverse and advantageous social environments as early as 3-months-old.

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来源期刊
Attachment & Human Development
Attachment & Human Development PSYCHOLOGY, DEVELOPMENTAL-
CiteScore
7.00
自引率
6.20%
发文量
11
期刊介绍: Attachment & Human Development is the leading forum for the presentation of empirical research, reviews and clinical case studies that reflect contemporary advances in attachment theory and research. The journal addresses the growing demand from the domains of psychology, psychiatry, psychotherapy and related disciplines including nursing and social work, for a clear presentation of ideas, methods and research based on attachment theory.
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