缺氧在脑肿瘤免疫反应中的作用

Jang Hyun Park, Heung Kyu Lee
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引用次数: 0

摘要

氧气是活细胞的重要组成部分。人体组织中的低氧水平(称为缺氧)会影响各种细胞类型的多种细胞功能,也是脑肿瘤的特征之一。在肿瘤微环境中,异常的血管和肿瘤细胞增强的耗氧量会诱发广泛的缺氧,这不仅会影响肿瘤细胞的特性,还会影响抗肿瘤免疫系统。虽然某些免疫反应需要缺氧,但缺氧通常会对免疫产生负面影响。缺氧会诱导肿瘤细胞侵袭、细胞对缺氧的适应以及肿瘤细胞的放射抗性。此外,缺氧还会限制免疫疗法的疗效,阻碍抗肿瘤反应。因此,了解缺氧在脑肿瘤中的作用对于开发有效的抗肿瘤疗法非常重要。在这篇综述中,我们将讨论支持缺氧在脑肿瘤中作用的最新证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The Role of Hypoxia in Brain Tumor Immune Responses.

The Role of Hypoxia in Brain Tumor Immune Responses.

The Role of Hypoxia in Brain Tumor Immune Responses.

The Role of Hypoxia in Brain Tumor Immune Responses.

Oxygen is a vital component of living cells. Low levels of oxygen in body tissues, known as hypoxia, can affect multiple cellular functions across a variety of cell types and are a hallmark of brain tumors. In the tumor microenvironment, abnormal vasculature and enhanced oxygen consumption by tumor cells induce broad hypoxia that affects not only tumor cell characteristics but also the antitumor immune system. Although some immune reactions require hypoxia, hypoxia generally negatively affects immunity. Hypoxia induces tumor cell invasion, cellular adaptations to hypoxia, and tumor cell radioresistance. In addition, hypoxia limits the efficacy of immunotherapy and hinders antitumor responses. Therefore, understanding the role of hypoxia in the brain tumor, which usually does not respond to immunotherapy alone is important for the development of effective anti-tumor therapies. In this review, we discuss recent evidence supporting the role of hypoxia in the context of brain tumors.

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