免疫疗法:急性髓性白血病的新疗法。

IF 1.5 Q3 HEMATOLOGY
Chen Tian, Zehui Chen
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引用次数: 1

摘要

虽然60%-70%的急性髓性白血病(AML)患者在常规化疗后可以完全缓解,但复发和治疗难治仍然是导致死亡的主要原因。此外,非常需要对所有身体虚弱的病人(由于年龄/合并症和与治疗有关的原因)采用较低强度的治疗方案。免疫治疗预期改善预后和减少毒性,这可能提供新的治疗原理。然而,开发针对AML的免疫疗法的主要困难之一是目标抗原也在健康的造血干细胞上显著表达;b细胞恶性肿瘤是不同的,因为CD20/CD19/健康b细胞很容易被替换。只有抗cd33抗体-药物缀合物吉妥珠单抗-ozogamicin被FDA批准用于AML。因此,药物开发仍然非常活跃,尽管它仍处于起步阶段。本文综述了基于抗体的药物、嵌合抗原受体疗法、检查点抑制剂和疫苗等免疫治疗药物治疗AML的临床结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Immune therapy: a new therapy for acute myeloid leukemia.

Immune therapy: a new therapy for acute myeloid leukemia.

Although complete remission could be achieved in about 60%-70% of acute myeloid leukemia (AML) patients after conventional chemotherapy, relapse and the state of being refractory to treatment remain the main cause of death. In addition, there is a great need for less intensive regimens for all medically frail patients (both due to age/comorbidity and treatment-related). Immune therapy anticipates improved prognosis and reduced toxicities, which may offer novel therapeutic rationales. However, one of the major difficulties in developing immune therapies against AML is that the target antigens are also significantly expressed on healthy hematopoietic stem cells; B-cell malignancies are different because CD20/CD19/healthy B-cells are readily replaceable. Only the anti-CD33 antibody-drug conjugate gemtuzumab-ozogamicin is approved by the FDA for AML. Thus, drug development remains extremely active, although it is still in its infancy. This review summarizes the clinical results of immune therapeutic agents for AML, such as antibody-based drugs, chimeric antigen receptor therapy, checkpoint inhibitors, and vaccines.

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来源期刊
CiteScore
1.70
自引率
0.00%
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审稿时长
10 weeks
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