双相情感障碍青少年的童年创伤和自我伤害。

IF 4.8 2区 医学 Q1 NEUROSCIENCES
Delfina Janiri, Michelangelo Di Luzio, Silvia Montanari, Daniele Hirsch, Alessio Simonetti, Lorenzo Moccia, Eliana Conte, Ilaria Contaldo, Chiara Veredice, Eugenio Mercuri, Gabriele Sani
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引用次数: 0

摘要

背景:青少年双相情感障碍(BD)与自我伤害行为的高风险相关。儿童创伤(CT)是一种相关的环境应激源,与双相障碍的诊断和成年后的自我伤害有关。目前还不清楚CT是否会影响青少年的自残风险。因此,本研究的目的是探讨青少年双相障碍伴自残和不伴自残的CT分布模式。方法:我们评估了273名参与者(13-25岁),96名符合DSM-5标准的青年BD患者和177名健康对照(HC)。使用儿童创伤问卷(CTQ)获得CT病史。使用多元统计模型检验CT与自残之间的关系。结果:超过45%的双相障碍患者报告终生自我伤害。与HC相比,BD自残组报告了更多的情感虐待、情感忽视、性虐待和身体虐待。没有自我伤害的BD组比HC组报告了更多的情感虐待。双相障碍自残组比无双相障碍自残组报告了更多的情感虐待和忽视。双相障碍自残组还报告了父母离异、住院、吸烟、使用抗癫痫药、抗精神病药和锂。情绪虐待是双相障碍青少年自我伤害的独立预测因子。结论:研究结果支持了评估CT的重要性,特别是情绪虐待,对有自我伤害风险的双相障碍青少年。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Childhood Trauma and Self-harm in Youths with Bipolar Disorders.

Background: Bipolar disorders (BD) in youth are associated with a high risk of self-harm behaviors. Childhood trauma (CT) is a relevant environmental stressor that is related to both BD diagnosis and self-harm in adulthood. It is not yet established whether CT may impact self-harm risk in youth. Therefore, the aim of this study was to investigate the distribution patterns of CT in youth BD with and without self-harm.

Methods: We assessed 273 participants (aged 13-25 years), 96 youths with BD according to DSM-5 criteria and 177 healthy controls (HC). History of CT was obtained using the Childhood Trauma Questionnaire (CTQ). The association between CT and self-harm was tested using multivariate statistical models.

Results: Over 45% of participants with BD reported lifetime self-harm. The BD Self-harm group reported more emotional abuse, emotional neglect, sexual abuse, and physical abuse than HC. The BD No-Self-harm group reported more emotional abuse than HC. The BD Self-harm group reported more emotional abuse and neglect than the BD No-Self-harm group. The BD Self-harm group also reported separated parents, hospitalizations, smoking, use of antiepileptics, antipsychotics and lithium. Emotional abuse was an independent predictor of self-harm in youths with BD.

Conclusion: Findings support the importance of assessing CT, in particular emotional abuse, in youth with BD at risk for self-harm.

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来源期刊
Current Neuropharmacology
Current Neuropharmacology 医学-神经科学
CiteScore
8.70
自引率
1.90%
发文量
369
审稿时长
>12 weeks
期刊介绍: Current Neuropharmacology aims to provide current, comprehensive/mini reviews and guest edited issues of all areas of neuropharmacology and related matters of neuroscience. The reviews cover the fields of molecular, cellular, and systems/behavioural aspects of neuropharmacology and neuroscience. The journal serves as a comprehensive, multidisciplinary expert forum for neuropharmacologists and neuroscientists.
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